diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index e6476c3df50..e086c060b58 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -100,7 +100,7 @@ mdurl==0.1.2
 mirakuru==3.0.2
 mistune==3.2.1
 more-itertools==11.1.0 ; platform_machine != 'ppc64le' and platform_machine != 's390x'
-msgpack==1.1.2
+msgpack==1.2.1
 multidict==6.7.1
 mypy==2.1.0
 mypy-extensions==1.1.0
diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index 37dcdf56781..2300062b59a 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -159,7 +159,7 @@ mistune==3.2.1
 more-itertools==11.1.0
 mrcfile==1.5.4
 msal==1.37.0
-msgpack==1.1.2
+msgpack==1.2.1
 multidict==6.7.1
 mypy-extensions==1.1.0
 networkx==3.4.2 ; python_full_version < '3.11'
diff --git a/lib/galaxy/dependencies/pinned-test-requirements.txt b/lib/galaxy/dependencies/pinned-test-requirements.txt
index 79ea1e28e62..2fa1f16394d 100644
--- a/lib/galaxy/dependencies/pinned-test-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-test-requirements.txt
@@ -78,7 +78,7 @@ matplotlib==3.10.9
 mdurl==0.1.2
 mirakuru==3.0.2
 mistune==3.2.1
-msgpack==1.1.2
+msgpack==1.2.1
 multidict==6.7.1
 mypy==2.1.0
 mypy-extensions==1.1.0