diff --git a/config/datatypes_conf.xml.sample b/config/datatypes_conf.xml.sample
index 5386cb0b72b..d3505088219 100644
--- a/config/datatypes_conf.xml.sample
+++ b/config/datatypes_conf.xml.sample
@@ -172,6 +172,7 @@
     <datatype extension="traml" type="galaxy.datatypes.proteomics:TraML" mimetype="application/xml" display_in_upload="true" />
     <datatype extension="featurexml" type="galaxy.datatypes.proteomics:FeatureXML" mimetype="application/xml" display_in_upload="true" />
     <datatype extension="consensusxml" type="galaxy.datatypes.proteomics:ConsensusXML" mimetype="application/xml" display_in_upload="true" />
+    <datatype extension="uniprotxml" type="galaxy.datatypes.proteomics:UniProtXML" mimetype="application/xml" display_in_upload="true" />
     <datatype extension="msp" type="galaxy.datatypes.proteomics:Msp" display_in_upload="true" />
     <datatype extension="splib_noindex" type="galaxy.datatypes.proteomics:SPLibNoIndex" display_in_upload="true" />
     <datatype extension="splib" type="galaxy.datatypes.proteomics:SPLib" display_in_upload="true" />
@@ -459,6 +460,7 @@
     <sniffer type="galaxy.datatypes.proteomics:TraML"/>
     <sniffer type="galaxy.datatypes.proteomics:MzIdentML"/>
     <sniffer type="galaxy.datatypes.proteomics:MzQuantML"/>
+    <sniffer type="galaxy.datatypes.proteomics:UniProtXML"/>
     <sniffer type="galaxy.datatypes.proteomics:Msp"/>
     <sniffer type="galaxy.datatypes.proteomics:SPLib"/>
     <sniffer type="galaxy.datatypes.proteomics:ThermoRAW"/>
diff --git a/lib/galaxy/datatypes/proteomics.py b/lib/galaxy/datatypes/proteomics.py
index ef74b010346..c510e30ae46 100644
--- a/lib/galaxy/datatypes/proteomics.py
+++ b/lib/galaxy/datatypes/proteomics.py
@@ -193,6 +193,12 @@ class TandemXML(ProteomicsXml):
     root = "bioml"
 
 
+class UniProtXML(ProteomicsXml):
+    file_ext = "uniprotxml"
+    blurb = "UniProt Proteome file"
+    root = "uniprot"
+
+
 class Mgf(Text):
     """Mascot Generic Format data"""
     file_ext = "mgf"