diff --git a/lib/galaxy/model/migrations/alembic/versions_gxy/f5a73c8b9d12_add_tool_index_table.py b/lib/galaxy/model/migrations/alembic/versions_gxy/f5a73c8b9d12_add_tool_index_table.py
new file mode 100644
index 00000000000..10ce6aa5dbf
--- /dev/null
+++ b/lib/galaxy/model/migrations/alembic/versions_gxy/f5a73c8b9d12_add_tool_index_table.py
@@ -0,0 +1,51 @@
+"""Add tool_index table for storing pre-computed tool index
+
+Revision ID: f5a73c8b9d12
+Revises: 28885b317f78
+Create Date: 2026-01-25 10:00:00.000000
+
+"""
+
+import sqlalchemy as sa
+from sqlalchemy.dialects import mysql
+
+from galaxy.model.migrations.util import (
+    create_table,
+    drop_table,
+)
+
+# revision identifiers, used by Alembic.
+revision = "f5a73c8b9d12"
+down_revision = "28885b317f78"
+branch_labels = None
+depends_on = None
+
+TABLE_NAME = "tool_index"
+
+
+def upgrade():
+    """Create tool_index table for storing pre-computed tool index.
+
+    This table stores a serialized ToolIndex object that provides
+    fast access to tool metadata for API responses without loading
+    full tool sources.
+    """
+    create_table(
+        TABLE_NAME,
+        sa.Column("id", sa.Integer, primary_key=True),
+        sa.Column("version", sa.String(64), nullable=False, unique=True),
+        sa.Column("data", sa.LargeBinary().with_variant(mysql.LONGBLOB(), "mysql"), nullable=False),
+        sa.Column("built_at", sa.DateTime, nullable=True),
+        sa.Column("create_time", sa.DateTime, nullable=False, server_default=sa.func.now()),
+        sa.Column(
+            "update_time",
+            sa.DateTime,
+            nullable=False,
+            server_default=sa.func.now(),
+            onupdate=sa.func.now(),
+        ),
+    )
+
+
+def downgrade():
+    drop_table(TABLE_NAME)