diff --git a/packages/files/setup.cfg b/packages/files/setup.cfg
index 00aeea918b0..3773e5acd12 100644
--- a/packages/files/setup.cfg
+++ b/packages/files/setup.cfg
@@ -34,6 +34,7 @@ include_package_data = True
 install_requires =
     galaxy-util[config-template,template]
     fs
+    setuptools<82  # TODO: remove once pyfilesystem2 drops pkg_resources (https://github.com/PyFilesystem/pyfilesystem2/issues/597)
     pydantic>=2.7.4
     typing-extensions
     fsspec
diff --git a/pyproject.toml b/pyproject.toml
index 3bf2df10d18..6cb1cdc602a 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -266,6 +266,7 @@ keep-runtime-typing = true
 constraint-dependencies = [
     "limits>=2.5.0",  # prefer not downgrading this to upgrading packaging
     "mirakuru!=3.0.0",  # https://github.com/dbfixtures/mirakuru/pull/949
+    "setuptools<82",  # https://github.com/PyFilesystem/pyfilesystem2/issues/597
     "scipy>=1.14.1; python_version>='3.10'",  # Python 3.13 support
 ]
 default-groups = []