From a05dc7b99a54b422039f067a07256dcf7626a8ea Mon Sep 17 00:00:00 2001
From: Qiang Gu <guqiang01@gmail.com>
Date: Sun, 11 Oct 2020 22:16:38 -0700
Subject: [PATCH 01/13] make avivator GEDA for ome tiff

---
 display_applications/image/avivator.xml       |  7 +++++++
 .../config/sample/datatypes_conf.xml.sample   |  4 +++-
 lib/galaxy/datatypes/images.py                | 20 +++++++++++++++++++
 .../pipfiles/default/pinned-requirements.txt  |  1 +
 4 files changed, 31 insertions(+), 1 deletion(-)
 create mode 100644 display_applications/image/avivator.xml

diff --git a/display_applications/image/avivator.xml b/display_applications/image/avivator.xml
new file mode 100644
index 00000000000..b1c54b8a89d
--- /dev/null
+++ b/display_applications/image/avivator.xml
@@ -0,0 +1,7 @@
+<display id="avivator" version="1.0.0" name="display at">
+    <link id="main" name="Avivator">
+        <url>http://avivator.gehlenborglab.org/?image_url=${qp($tiff_file.url)}</url>
+        <param type="data" name="tiff_file" url="galaxy_${DATASET_HASH}.ome.tiff" allow_cors="true"/>
+        <param type="data" name="offsets_file" url="galaxy_${DATASET_HASH}.offsets.json" metadata="offsets" allow_cors="true"/>
+    </link>
+</display>
diff --git a/lib/galaxy/config/sample/datatypes_conf.xml.sample b/lib/galaxy/config/sample/datatypes_conf.xml.sample
index 583a82ec613..645080c91aa 100644
--- a/lib/galaxy/config/sample/datatypes_conf.xml.sample
+++ b/lib/galaxy/config/sample/datatypes_conf.xml.sample
@@ -204,7 +204,9 @@
     <datatype extension="svs" type="galaxy.datatypes.images:Tiff" subclass="true" display_in_upload="false"/>
     <datatype extension="scn" type="galaxy.datatypes.images:Tiff" subclass="true" display_in_upload="false"/>
     <datatype extension="bif" type="galaxy.datatypes.images:Tiff" subclass="true" display_in_upload="false"/>
-    <datatype extension="ome.tiff" type="galaxy.datatypes.images:Tiff" subclass="true" display_in_upload="true"/>
+    <datatype extension="ome.tiff" type="galaxy.datatypes.images:OMETiff" display_in_upload="true">
+      <display file="image/avivator.xml"/>
+    </datatype>
     <datatype extension="vms" type="galaxy.datatypes.images:Hamamatsu" mimetype="image/hamamatsu"/>
     <datatype extension="vmu" type="galaxy.datatypes.images:Hamamatsu" subclass="true" display_in_upload="false"/>
     <datatype extension="ndpi" type="galaxy.datatypes.images:Hamamatsu" subclass="true" display_in_upload="false"/>
diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index 1a3ad984643..85975ca8281 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -2,10 +2,13 @@
 Image classes
 """
 import base64
+import json
 import logging
+import tifffile
 import zipfile
 from urllib.parse import quote_plus
 
+from galaxy.datatypes.metadata import FileParameter, MetadataElement
 from galaxy.datatypes.text import Html as HtmlFromText
 from galaxy.util import nice_size
 from galaxy.util.image_util import check_image_type
@@ -73,6 +76,23 @@ class Tiff(Image):
     file_ext = "tiff"
 
 
+class OMETiff(Tiff):
+    file_ext = "ome.tiff"
+    MetadataElement(name="offsets", desc="Offsets File", param=FileParameter, file_ext="json", readonly=True, no_value=None, visible=False, optional=True)
+
+    def set_meta(self, dataset, overwrite=True, **kwd):
+
+        spec_key = 'offsets'
+        offsets_file = dataset.metadata.offsets
+        if not offsets_file:
+            offsets_file = dataset.metadata.spec[spec_key].param.new_file(dataset=dataset)
+        with tifffile.TiffFile(dataset.file_name) as tif:
+            offsets = [page.offset for page in tif.pages]
+        with open(offsets_file.file_name, 'w') as f:
+            json.dump(offsets, f)
+        dataset.metadata.offsets = offsets_file
+
+
 class Hamamatsu(Image):
     file_ext = "vms"
 
diff --git a/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt b/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
index bc6b194f9a0..0117b50b1f1 100644
--- a/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
@@ -177,6 +177,7 @@ stevedore==1.32.0
 svgwrite==1.3.1
 tempita==0.5.2
 tenacity==4.12.0
+tifffile>=2018.10.18
 tqdm==4.46.1
 typing-extensions==3.7.4.2
 typing==3.7.4.1 ; python_version < '3.5'

From 336d84f44f8ede256fb1952cbe1f0f0777eb8ff7 Mon Sep 17 00:00:00 2001
From: Qiang Gu <guqiang01@gmail.com>
Date: Wed, 14 Oct 2020 18:30:12 -0700
Subject: [PATCH 02/13] add ome.tiff datatype sniffer

---
 lib/galaxy/config/sample/datatypes_conf.xml.sample | 1 +
 lib/galaxy/util/image_util.py                      | 8 +++++++-
 2 files changed, 8 insertions(+), 1 deletion(-)

diff --git a/lib/galaxy/config/sample/datatypes_conf.xml.sample b/lib/galaxy/config/sample/datatypes_conf.xml.sample
index 645080c91aa..fd1c5ee230d 100644
--- a/lib/galaxy/config/sample/datatypes_conf.xml.sample
+++ b/lib/galaxy/config/sample/datatypes_conf.xml.sample
@@ -1004,6 +1004,7 @@
     <sniffer type="galaxy.datatypes.binary:RData"/>
     <sniffer type="galaxy.datatypes.images:Jpg"/>
     <sniffer type="galaxy.datatypes.images:Png"/>
+    <sniffer type="galaxy.datatypes.images:OMETiff"/>
     <sniffer type="galaxy.datatypes.images:Tiff"/>
     <sniffer type="galaxy.datatypes.images:Bmp"/>
     <sniffer type="galaxy.datatypes.images:Gif"/>
diff --git a/lib/galaxy/util/image_util.py b/lib/galaxy/util/image_util.py
index d24a75f1072..ad2c285ea02 100644
--- a/lib/galaxy/util/image_util.py
+++ b/lib/galaxy/util/image_util.py
@@ -2,6 +2,7 @@
 
 import imghdr
 import logging
+import tifffile
 
 try:
     import Image as PIL
@@ -28,7 +29,12 @@ def image_type(filename):
     if not fmt:
         fmt = imghdr.what(filename)
     if fmt:
-        return fmt.upper()
+        fmt = fmt.upper()
+        if fmt == 'TIFF':
+            with tifffile.TiffFile(filename) as tif:
+                if tif.is_ome:
+                    fmt = 'OME.TIFF'
+        return fmt
     else:
         return False
 

From 6694473165c60f8715ff273434279cb470d69cc4 Mon Sep 17 00:00:00 2001
From: Qiang Gu <guqiang01@gmail.com>
Date: Wed, 14 Oct 2020 18:36:46 -0700
Subject: [PATCH 03/13] make set_meta relaxed for ome.tiff datatype

---
 lib/galaxy/datatypes/images.py                | 22 ++++++++++---------
 .../pipfiles/default/pinned-requirements.txt  |  2 +-
 2 files changed, 13 insertions(+), 11 deletions(-)

diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index 85975ca8281..c561776dd92 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -81,16 +81,18 @@ class OMETiff(Tiff):
     MetadataElement(name="offsets", desc="Offsets File", param=FileParameter, file_ext="json", readonly=True, no_value=None, visible=False, optional=True)
 
     def set_meta(self, dataset, overwrite=True, **kwd):
-
-        spec_key = 'offsets'
-        offsets_file = dataset.metadata.offsets
-        if not offsets_file:
-            offsets_file = dataset.metadata.spec[spec_key].param.new_file(dataset=dataset)
-        with tifffile.TiffFile(dataset.file_name) as tif:
-            offsets = [page.offset for page in tif.pages]
-        with open(offsets_file.file_name, 'w') as f:
-            json.dump(offsets, f)
-        dataset.metadata.offsets = offsets_file
+        try:
+            spec_key = 'offsets'
+            offsets_file = dataset.metadata.offsets
+            if not offsets_file:
+                offsets_file = dataset.metadata.spec[spec_key].param.new_file(dataset=dataset)
+            with tifffile.TiffFile(dataset.file_name) as tif:
+                offsets = [page.offset for page in tif.pages]
+            with open(offsets_file.file_name, 'w') as f:
+                json.dump(offsets, f)
+            dataset.metadata.offsets = offsets_file
+        except:
+            pass
 
 
 class Hamamatsu(Image):
diff --git a/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt b/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
index 0117b50b1f1..512f9f13b4d 100644
--- a/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pipfiles/default/pinned-requirements.txt
@@ -177,7 +177,7 @@ stevedore==1.32.0
 svgwrite==1.3.1
 tempita==0.5.2
 tenacity==4.12.0
-tifffile>=2018.10.18
+tifffile==2020.9.3
 tqdm==4.46.1
 typing-extensions==3.7.4.2
 typing==3.7.4.1 ; python_version < '3.5'

From c1bbce6cb4f2fed680b75f14e910843d0953e91e Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Tue, 2 Mar 2021 18:00:03 -0800
Subject: [PATCH 04/13] Add a test for ome.tiff datatype

---
 lib/galaxy/datatypes/images.py           |   5 ++++-
 lib/galaxy_test/api/test_tools_upload.py |   7 +++++++
 test-data/1.ome.tiff                     | Bin 0 -> 50475 bytes
 3 files changed, 11 insertions(+), 1 deletion(-)
 create mode 100644 test-data/1.ome.tiff

diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index cf4f381be71..38cc3baed38 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -11,7 +11,10 @@ from urllib.parse import quote_plus
 import numpy as np
 
 from galaxy.datatypes.binary import Binary
-from galaxy.datatypes.metadata import FileParameter, MetadataElement
+from galaxy.datatypes.metadata import (
+    FileParameter,
+    MetadataElement,
+)
 from galaxy.datatypes.text import Html as HtmlFromText
 from galaxy.util import nice_size
 from galaxy.util.image_util import check_image_type
diff --git a/lib/galaxy_test/api/test_tools_upload.py b/lib/galaxy_test/api/test_tools_upload.py
index af035505f09..09c696067dd 100644
--- a/lib/galaxy_test/api/test_tools_upload.py
+++ b/lib/galaxy_test/api/test_tools_upload.py
@@ -223,6 +223,13 @@ class ToolsUploadTestCase(ApiTestCase):
             tiff_metadata = self._upload_and_get_details(fh, file_type="auto")
         self.assertEqual(tiff_metadata["file_ext"], "tiff")
 
+    @skip_without_datatype("ome.tiff")
+    def test_image_upload_auto(self):
+        tiff_path = TestDataResolver().get_filename("1.ome.tiff")
+        with open(tiff_path, "rb") as fh:
+            tiff_metadata = self._upload_and_get_details(fh, file_type="auto")
+        self.assertEqual(tiff_metadata["file_ext"], "ome.tiff")
+
     @uses_test_history(require_new=False)
     def test_newlines_stage_fetch(self, history_id):
         job = {
diff --git a/test-data/1.ome.tiff b/test-data/1.ome.tiff
new file mode 100644
index 0000000000000000000000000000000000000000..57b6b411b2c9f1fdccdef20844ae4758df657907
GIT binary patch
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From e739866eefe79a05a13492e763e759d8443b6210 Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Tue, 2 Mar 2021 20:03:32 -0800
Subject: [PATCH 05/13] Make sniff method for ome.tiff datatype

---
 lib/galaxy/datatypes/images.py           | 13 +++++++++++--
 lib/galaxy/util/image_util.py            |  8 +-------
 lib/galaxy_test/api/test_tools_upload.py |  2 +-
 3 files changed, 13 insertions(+), 10 deletions(-)

diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index 38cc3baed38..de004766082 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -4,11 +4,11 @@ Image classes
 import base64
 import json
 import logging
-import tifffile
 import zipfile
 from urllib.parse import quote_plus
 
 import numpy as np
+import tifffile
 
 from galaxy.datatypes.binary import Binary
 from galaxy.datatypes.metadata import (
@@ -99,9 +99,18 @@ class OMETiff(Tiff):
             with open(offsets_file.file_name, 'w') as f:
                 json.dump(offsets, f)
             dataset.metadata.offsets = offsets_file
-        except:
+        except Exception:
             pass
 
+    def sniff(self, filename):
+        is_tiff = Tiff().sniff(filename)
+        if not is_tiff:
+            return False
+        with tifffile.TiffFile(filename) as tif:
+            if tif.is_ome:
+                return True
+        return False
+
 
 class Hamamatsu(Image):
     file_ext = "vms"
diff --git a/lib/galaxy/util/image_util.py b/lib/galaxy/util/image_util.py
index ad2c285ea02..d24a75f1072 100644
--- a/lib/galaxy/util/image_util.py
+++ b/lib/galaxy/util/image_util.py
@@ -2,7 +2,6 @@
 
 import imghdr
 import logging
-import tifffile
 
 try:
     import Image as PIL
@@ -29,12 +28,7 @@ def image_type(filename):
     if not fmt:
         fmt = imghdr.what(filename)
     if fmt:
-        fmt = fmt.upper()
-        if fmt == 'TIFF':
-            with tifffile.TiffFile(filename) as tif:
-                if tif.is_ome:
-                    fmt = 'OME.TIFF'
-        return fmt
+        return fmt.upper()
     else:
         return False
 
diff --git a/lib/galaxy_test/api/test_tools_upload.py b/lib/galaxy_test/api/test_tools_upload.py
index 09c696067dd..1f026e9c60e 100644
--- a/lib/galaxy_test/api/test_tools_upload.py
+++ b/lib/galaxy_test/api/test_tools_upload.py
@@ -224,7 +224,7 @@ class ToolsUploadTestCase(ApiTestCase):
         self.assertEqual(tiff_metadata["file_ext"], "tiff")
 
     @skip_without_datatype("ome.tiff")
-    def test_image_upload_auto(self):
+    def test_ometiff_upload_sniff(self):
         tiff_path = TestDataResolver().get_filename("1.ome.tiff")
         with open(tiff_path, "rb") as fh:
             tiff_metadata = self._upload_and_get_details(fh, file_type="auto")

From 201b4090b0e3cb247d038b90965207eb75f80044 Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Tue, 2 Mar 2021 20:42:30 -0800
Subject: [PATCH 06/13] Fix tifffile in dependencies

---
 lib/galaxy/dependencies/dev-requirements.txt | 1 +
 1 file changed, 1 insertion(+)

diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index 4c00a59e444..ae5f7ef7eb8 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -218,6 +218,7 @@ svgwrite==1.4.1; python_version >= "3.6"
 tempita==0.5.2
 tenacity==6.3.1
 testfixtures==6.17.1
+tifffile==2021.2.26
 toml==0.10.2; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version >= "3.6"
 tqdm==4.56.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 twill==2.0.1

From 7fde8fe7eaf8bf9053c7cff6d668d9d6405b3a73 Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Wed, 3 Mar 2021 11:30:58 -0800
Subject: [PATCH 07/13] Revise test for ome.tiff datatype

---
 lib/galaxy/datatypes/test/1.ome.tiff     | Bin 0 -> 29775 bytes
 lib/galaxy_test/api/test_tools_upload.py |   7 -------
 pyproject.toml                           |   1 +
 test-data/1.ome.tiff                     | Bin 50475 -> 0 bytes
 4 files changed, 1 insertion(+), 7 deletions(-)
 create mode 100644 lib/galaxy/datatypes/test/1.ome.tiff
 delete mode 100644 test-data/1.ome.tiff

diff --git a/lib/galaxy/datatypes/test/1.ome.tiff b/lib/galaxy/datatypes/test/1.ome.tiff
new file mode 100644
index 0000000000000000000000000000000000000000..805dd66e62f4de52e19240eb05bdf146569bfb1e
GIT binary patch
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diff --git a/lib/galaxy_test/api/test_tools_upload.py b/lib/galaxy_test/api/test_tools_upload.py
index 1f026e9c60e..af035505f09 100644
--- a/lib/galaxy_test/api/test_tools_upload.py
+++ b/lib/galaxy_test/api/test_tools_upload.py
@@ -223,13 +223,6 @@ class ToolsUploadTestCase(ApiTestCase):
             tiff_metadata = self._upload_and_get_details(fh, file_type="auto")
         self.assertEqual(tiff_metadata["file_ext"], "tiff")
 
-    @skip_without_datatype("ome.tiff")
-    def test_ometiff_upload_sniff(self):
-        tiff_path = TestDataResolver().get_filename("1.ome.tiff")
-        with open(tiff_path, "rb") as fh:
-            tiff_metadata = self._upload_and_get_details(fh, file_type="auto")
-        self.assertEqual(tiff_metadata["file_ext"], "ome.tiff")
-
     @uses_test_history(require_new=False)
     def test_newlines_stage_fetch(self, history_id):
         job = {
diff --git a/pyproject.toml b/pyproject.toml
index 00608e54a9c..cfe56a65ac7 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -74,6 +74,7 @@ sqlparse = "*"
 starlette = "*"
 starlette-context = "*"
 svgwrite = "*"
+tifffile = "*"
 uvicorn = "*"
 WebOb = "*"
 Whoosh = "*"
diff --git a/test-data/1.ome.tiff b/test-data/1.ome.tiff
deleted file mode 100644
index 57b6b411b2c9f1fdccdef20844ae4758df657907..0000000000000000000000000000000000000000
GIT binary patch
literal 0
HcmV?d00001

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From 5686c368f6210367a80f60f64fcb7139cdfb9f7b Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Tue, 16 Mar 2021 22:28:58 -0700
Subject: [PATCH 08/13] Update tifffile version

---
 lib/galaxy/dependencies/dev-requirements.txt    | 2 +-
 lib/galaxy/dependencies/pinned-requirements.txt | 2 +-
 packages/data/requirements.txt                  | 1 +
 3 files changed, 3 insertions(+), 2 deletions(-)

diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index bb4ca5735e7..ea635296ea3 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -219,7 +219,7 @@ svgwrite==1.4.1; python_version >= "3.6"
 tempita==0.5.2
 tenacity==6.3.1
 testfixtures==6.17.1
-tifffile==2021.2.26
+tifffile==2021.3.16
 toml==0.10.2; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version >= "3.6"
 tqdm==4.56.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 twill==2.0.1
diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index 747c88a2c90..a46a4828fdb 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -175,7 +175,7 @@ stevedore==3.3.0; python_version >= "3.6"
 svgwrite==1.4.1; python_version >= "3.6"
 tempita==0.5.2
 tenacity==6.3.1
-tifffile==2021.2.26
+tifffile==2021.3.16
 tqdm==4.56.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 typing-extensions==3.7.4.3; python_version >= "3.6" and python_version < "3.8"
 tzlocal==2.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version < "4"
diff --git a/packages/data/requirements.txt b/packages/data/requirements.txt
index c60f014771d..4aa35d837a5 100644
--- a/packages/data/requirements.txt
+++ b/packages/data/requirements.txt
@@ -15,4 +15,5 @@ social-auth-core[openidconnect]==3.3.0
 SQLAlchemy>=1.3.0,<1.4.0  # https://github.com/kvesteri/sqlalchemy-utils/issues/474
 sqlalchemy-migrate
 sqlalchemy-utils
+tifffile
 WebOb

From a0470246539479d1484cde19f11ce11ba32e3e37 Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Wed, 17 Mar 2021 10:46:12 -0700
Subject: [PATCH 09/13] Revise sniff method for OMETiff

---
 lib/galaxy/datatypes/images.py | 33 +++++++++++++++------------------
 1 file changed, 15 insertions(+), 18 deletions(-)

diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index de004766082..94fdcbf4483 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -89,27 +89,24 @@ class OMETiff(Tiff):
     MetadataElement(name="offsets", desc="Offsets File", param=FileParameter, file_ext="json", readonly=True, no_value=None, visible=False, optional=True)
 
     def set_meta(self, dataset, overwrite=True, **kwd):
-        try:
-            spec_key = 'offsets'
-            offsets_file = dataset.metadata.offsets
-            if not offsets_file:
-                offsets_file = dataset.metadata.spec[spec_key].param.new_file(dataset=dataset)
-            with tifffile.TiffFile(dataset.file_name) as tif:
-                offsets = [page.offset for page in tif.pages]
-            with open(offsets_file.file_name, 'w') as f:
-                json.dump(offsets, f)
-            dataset.metadata.offsets = offsets_file
-        except Exception:
-            pass
+        spec_key = 'offsets'
+        offsets_file = dataset.metadata.offsets
+        if not offsets_file:
+            offsets_file = dataset.metadata.spec[spec_key].param.new_file(dataset=dataset)
+        with tifffile.TiffFile(dataset.file_name) as tif:
+            offsets = [page.offset for page in tif.pages]
+        with open(offsets_file.file_name, 'w') as f:
+            json.dump(offsets, f)
+        dataset.metadata.offsets = offsets_file
 
     def sniff(self, filename):
-        is_tiff = Tiff().sniff(filename)
-        if not is_tiff:
+        try:
+            with tifffile.TiffFile(filename) as tif:
+                if tif.is_ome:
+                    return True
+                return False
+        except tifffile.TiffFileError:
             return False
-        with tifffile.TiffFile(filename) as tif:
-            if tif.is_ome:
-                return True
-        return False
 
 
 class Hamamatsu(Image):

From bf63abd293d3efed7a314ee0ae6fa93eca2c911b Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Wed, 17 Mar 2021 11:00:03 -0700
Subject: [PATCH 10/13] Remove error catch for sniff method

---
 lib/galaxy/datatypes/images.py | 11 ++++-------
 1 file changed, 4 insertions(+), 7 deletions(-)

diff --git a/lib/galaxy/datatypes/images.py b/lib/galaxy/datatypes/images.py
index 94fdcbf4483..7fa5bccdb68 100644
--- a/lib/galaxy/datatypes/images.py
+++ b/lib/galaxy/datatypes/images.py
@@ -100,13 +100,10 @@ class OMETiff(Tiff):
         dataset.metadata.offsets = offsets_file
 
     def sniff(self, filename):
-        try:
-            with tifffile.TiffFile(filename) as tif:
-                if tif.is_ome:
-                    return True
-                return False
-        except tifffile.TiffFileError:
-            return False
+        with tifffile.TiffFile(filename) as tif:
+            if tif.is_ome:
+                return True
+        return False
 
 
 class Hamamatsu(Image):

From 3278d01dcb5dedc2ea289f53452b73e9cf46691d Mon Sep 17 00:00:00 2001
From: qiagu <guqiang01@gmail.com>
Date: Wed, 7 Apr 2021 10:37:05 -0700
Subject: [PATCH 11/13] Lower down tifffile version to fit python 3.6

---
 lib/galaxy/dependencies/dev-requirements.txt    | 2 +-
 lib/galaxy/dependencies/pinned-requirements.txt | 2 +-
 2 files changed, 2 insertions(+), 2 deletions(-)

diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index 0453f7eb7ee..7f828096e0d 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -226,7 +226,7 @@ svgwrite==1.4.1; python_version >= "3.6"
 tempita==0.5.2
 tenacity==7.0.0
 testfixtures==6.17.1
-tifffile==2021.3.16
+tifffile==2020.9.3
 toml==0.10.2; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.3.0" and python_version >= "3.6"
 tqdm==4.59.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 twill==3.0
diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index b8561ac2899..90399d097fd 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -179,7 +179,7 @@ stevedore==3.3.0; python_version >= "3.6"
 svgwrite==1.4.1; python_version >= "3.6"
 tempita==0.5.2
 tenacity==7.0.0
-tifffile==2021.3.16
+tifffile==2020.9.3
 tqdm==4.59.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 typing-extensions==3.7.4.3; python_version >= "3.6" and python_version < "3.8"
 tzlocal==2.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"

From 66f8ad90a0ec21077d6d87ff0193f7b65132b225 Mon Sep 17 00:00:00 2001
From: mvdbeek <m.vandenbeek@gmail.com>
Date: Thu, 8 Apr 2021 09:52:36 +0200
Subject: [PATCH 12/13] Add pyproject.toml pin

---
 pyproject.toml | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/pyproject.toml b/pyproject.toml
index 1e516fedbe3..b6aa16e2369 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -76,7 +76,7 @@ sqlparse = "*"
 starlette = "*"
 starlette-context = {version = "*", python = ">=3.7"}
 svgwrite = "*"
-tifffile = "*"
+tifffile = "<=2020.9.3"  # Last version compatible with python 3.6
 uvicorn = "*"
 WebOb = "*"
 Whoosh = "*"

From 17adb6aa1ad2e1d29555ab96ae1027dddf864400 Mon Sep 17 00:00:00 2001
From: mvdbeek <m.vandenbeek@gmail.com>
Date: Thu, 8 Apr 2021 09:53:54 +0200
Subject: [PATCH 13/13] Pin data package requirement

---
 packages/data/requirements.txt | 2 +-
 1 file changed, 1 insertion(+), 1 deletion(-)

diff --git a/packages/data/requirements.txt b/packages/data/requirements.txt
index 0bce14256f7..8fa2fe55212 100644
--- a/packages/data/requirements.txt
+++ b/packages/data/requirements.txt
@@ -16,5 +16,5 @@ social-auth-core[openidconnect]==3.3.0
 SQLAlchemy>=1.3.0,<1.4.0  # https://github.com/kvesteri/sqlalchemy-utils/issues/474
 sqlalchemy-migrate
 sqlalchemy-utils
-tifffile
+tifffile<=2020.9.3  # Last version compatible with python 3.6
 WebOb