diff --git a/lib/galaxy/managers/jobs.py b/lib/galaxy/managers/jobs.py
index 8a6195ba15f..6418967f3a5 100644
--- a/lib/galaxy/managers/jobs.py
+++ b/lib/galaxy/managers/jobs.py
@@ -79,6 +79,7 @@ from galaxy.model.index_filter_util import (
     text_column_filter,
 )
 from galaxy.model.scoped_session import galaxy_scoped_session
+from galaxy.schema.credentials import CredentialsContext
 from galaxy.schema.schema import (
     JobIndexQueryPayload,
     JobIndexSortByEnum,
@@ -2186,6 +2187,9 @@ class JobSubmitter:
             target_history = request_context.history
             use_cached_jobs = request.use_cached_jobs
             rerun_remap_job_id = request.rerun_remap_job_id
+            credentials_context: Optional[CredentialsContext] = None
+            if request.credentials_context:
+                credentials_context = CredentialsContext(root=request.credentials_context)
             tool_state, new_hdas = self.dereference(request_context, tool, request, tool_request)
             to_materialize_list = [p for p in new_hdas if not p.request.deferred]
             for to_materialize in to_materialize_list:
@@ -2201,6 +2205,7 @@ class JobSubmitter:
                 history=target_history,
                 use_cached_job=use_cached_jobs,
                 rerun_remap_job_id=rerun_remap_job_id,
+                credentials_context=credentials_context,
             )
             tool_request.state = ToolRequest.states.SUBMITTED
             sa_session.add(tool_request)
diff --git a/lib/galaxy/schema/tasks.py b/lib/galaxy/schema/tasks.py
index 8c6ef67e7f8..5d5f173d2dd 100644
--- a/lib/galaxy/schema/tasks.py
+++ b/lib/galaxy/schema/tasks.py
@@ -9,6 +9,7 @@ from pydantic import Field
 
 from galaxy.util.hash_util import HashFunctionNameEnum
 from . import PdfDocumentType
+from .credentials import ServiceCredentialsContext
 from .schema import (
     BcoGenerationParametersMixin,
     DatasetSourceType,
@@ -186,3 +187,4 @@ class QueueJobs(Model):
     user: RequestUser  # TODO: test anonymous users through this submission path
     use_cached_jobs: bool
     rerun_remap_job_id: Optional[int]  # link to a job to rerun & remap
+    credentials_context: Optional[list[ServiceCredentialsContext]] = None  # credential context for vault-based credential injection
diff --git a/lib/galaxy/tools/actions/__init__.py b/lib/galaxy/tools/actions/__init__.py
index 79890964b4b..15ae62e1599 100644
--- a/lib/galaxy/tools/actions/__init__.py
+++ b/lib/galaxy/tools/actions/__init__.py
@@ -972,6 +972,7 @@ class DefaultToolAction(ToolAction):
         if credentials_context is None:
             return
 
+        # Create database associations for vault-based credentials
         for service_context in credentials_context.root:
             association = JobCredentialsContextAssociation(
                 job=job,
diff --git a/lib/galaxy/webapps/galaxy/services/jobs.py b/lib/galaxy/webapps/galaxy/services/jobs.py
index ffc3a054983..781c58a78d1 100644
--- a/lib/galaxy/webapps/galaxy/services/jobs.py
+++ b/lib/galaxy/webapps/galaxy/services/jobs.py
@@ -47,6 +47,7 @@ from galaxy.schema.schema import (
     AsyncTaskResultSummary,
     JobIndexQueryPayload,
 )
+from galaxy.schema.credentials import ServiceCredentialsContext
 from galaxy.schema.tasks import (
     QueueJobs,
     ToolSource,
@@ -90,6 +91,9 @@ class JobRequest(BaseModel):
         default=None, title="rerun_remap_job_id", description="TODO"
     )
     send_email_notification: bool = Field(default=False, title="Send Email Notification", description="TODO")
+    credentials_context: Optional[list[ServiceCredentialsContext]] = Field(
+        default=None, title="credentials_context", description="Credential context for tool execution."
+    )
 
 
 class JobCreateResponse(BaseModel):
@@ -286,6 +290,7 @@ class JobsService(ServiceBase):
             tool_request_id=tool_request_id,
             use_cached_jobs=job_request.use_cached_jobs or False,
             rerun_remap_job_id=job_request.rerun_remap_job_id,
+            credentials_context=job_request.credentials_context,
         )
         result = queue_jobs.delay(request=task_request)
         return JobCreateResponse(
diff --git a/lib/galaxy/webapps/galaxy/services/tools.py b/lib/galaxy/webapps/galaxy/services/tools.py
index ef469889acb..c508b857e65 100644
--- a/lib/galaxy/webapps/galaxy/services/tools.py
+++ b/lib/galaxy/webapps/galaxy/services/tools.py
@@ -352,7 +352,7 @@ class ToolsService(ServiceBase):
             inputs.get("use_cached_job", "false")
         )
         preferred_object_store_id = payload.get("preferred_object_store_id")
-        credentials_context = payload.get("credentials_context")
+        credentials_context_raw = payload.get("credentials_context")
         input_format = str(payload.get("input_format", "legacy"))
         if input_format not in get_args(InputFormatT):
             raise exceptions.RequestParameterInvalidException(f"input_format invalid {input_format}")
@@ -360,6 +360,12 @@ class ToolsService(ServiceBase):
         if "data_manager_mode" in payload:
             incoming["__data_manager_mode"] = payload["data_manager_mode"]
         tags = payload.get("__tags")
+
+        # Handle credentials_context
+        credentials_context: Optional[CredentialsContext] = None
+        if credentials_context_raw:
+            credentials_context = CredentialsContext(root=credentials_context_raw)
+
         vars = tool.handle_input(
             trans,
             incoming,
@@ -367,7 +373,7 @@ class ToolsService(ServiceBase):
             use_cached_job=use_cached_job,
             input_format=input_format,
             preferred_object_store_id=preferred_object_store_id,
-            credentials_context=CredentialsContext(root=credentials_context) if credentials_context else None,
+            credentials_context=credentials_context,
             tags=tags,
         )