diff --git a/setup.py b/setup.py
index d1dfc85fd64..5cb64670288 100644
--- a/setup.py
+++ b/setup.py
@@ -5,85 +5,11 @@ from setuptools import setup, find_packages
 
 
 readme = open('README.rst').read()
-
-GALAXY_PACKAGE = os.environ.get("GALAXY_PACKAGE", "galaxy-lib")
 VERSION = None
 
 
-def _find_packages(base):
-    r = []
-    for sub in find_packages(os.sep.join(['lib'] + base.split('.'))):
-        print 'Found package', '.'.join([base, sub])
-        r.append('.'.join([base, sub]))
-    return r
-
-
-if GALAXY_PACKAGE == "galaxy-lib":
-    requirements = []
-    base_packages = [
-        'galaxy.datatypes',
-        'galaxy.exceptions',
-        'galaxy.jobs.metrics',
-        'galaxy.objectstore',
-        'galaxy.tools',
-        'galaxy.util',
-    ]
-    package_data = [
-        'exceptions/error_codes.json',
-        'datatypes/converters/*.xml',
-        'datatypes/display_applications/configs/*/*.xml',
-        'datatypes/set_metadata_tool.xml',
-        'tools/imp_exp/imp_history_from_archive.xml',
-        'tools/imp_exp/exp_history_to_archive.xml',
-    ]
-elif GALAXY_PACKAGE == "galaxy":
-    requirements = [
-        'galaxy-lib',
-    ]
-    base_packages = [
-        'galaxy.actions',
-        'galaxy.auth',
-        'galaxy.dataset_collections',
-        'galaxy.dependencies',
-        'galaxy.external_services',
-        'galaxy.forms',
-        'galaxy.jobs',
-        'galaxy.managers',
-        'galaxy.model',
-        'galaxy.openid',
-        'galaxy.quota',
-        'galaxy.sample_tracking',
-        'galaxy.security',
-        'galaxy.tags',
-        'galaxy.tours',
-        'galaxy.visualization',
-        'galaxy.web',
-        'galaxy.webapps',
-        'galaxy.workflow',
-        'galaxy.work',
-    ]
-    package_data = [
-        'jobs/runners/util/job_script/DEFAULT_JOB_FILE_TEMPLATE.sh',
-        'jobs/runners/util/job_script/CLUSTER_SLOTS_STATEMENT.sh',
-        'model/migrate/migrate.cfg',
-        'dependencies/*.txt',
-    ]
-elif GALAXY_PACKAGE == 'tool-shed':
-    requirements = [
-        'galaxy-app',
-    ]
-    packages = ['tool_shed'] + _find_packages('tool_shed')
-    package_data = []
-else:
-    sys.stderr.write('ERROR: Unknown package name: {}\n'.format(GALAXY_PACKAGE))
-    sys.exit(1)
-
-
-if GALAXY_PACKAGE.startswith('galaxy'):
-    packages = ['galaxy']
-    for base_package in base_packages:
-        packages.append(base_package)
-        packages.extend(_find_packages(base_package))
+# TODO: detect if we are not running from pip (inspect the stack?) and if not,
+# suggest using `pip install -i https://wheels.galaxyproject.org/simple .`
 
 
 # sets VERSION (also VERSION_MAJOR and VERSION_MINOR)
@@ -92,22 +18,32 @@ execfile('lib/galaxy/version.py')
 scripts = ["scripts/galaxy"]
 
 setup(
-    name=GALAXY_PACKAGE,
+    name='galaxy',
     version=VERSION,
     description='Galaxy (http://galaxyproject.org/).',
     long_description=readme,
     author='Galaxy Project',
     author_email='galaxy-dev@lists.galaxyproject.org',
     url='https://github.com/galaxyproject/galaxy',
-    packages=packages,
+    packages=find_packages('lib'),
     entry_points='''
         [console_scripts]
         galaxy-paster=galaxy.util.pastescript.serve:run
         galaxy-main=galaxy.main:main
     ''',
-    scripts=scripts,
     package_data={
-        'galaxy': package_data,
+        'galaxy': [
+            'exceptions/error_codes.json',
+            'datatypes/converters/*.xml',
+            'datatypes/display_applications/configs/*/*.xml',
+            'datatypes/set_metadata_tool.xml',
+            'jobs/runners/util/job_script/DEFAULT_JOB_FILE_TEMPLATE.sh',
+            'jobs/runners/util/job_script/CLUSTER_SLOTS_STATEMENT.sh',
+            'tools/imp_exp/imp_history_from_archive.xml',
+            'tools/imp_exp/exp_history_to_archive.xml',
+            'model/migrate/migrate.cfg',
+            'dependencies/*.txt',
+        ],
         'tool_shed': [
             'galaxy_install/migrate/migrate.cfg',
             'scripts/bootstrap_tool_shed/parse_run_sh_args.sh',
@@ -117,7 +53,60 @@ setup(
     },
     package_dir={'': 'lib'},
     include_package_data=True,
-    install_requires=requirements,
+    dependency_links=['https://wheels.galaxyproject.org/packages'],
+    setup_requires=['pip>=8.1'],
+    # FIXME: read requirements.txt into a list...
+    install_requires=[
+        'bx-python==0.7.3',
+        'MarkupSafe==0.23',
+        'PyYAML==3.11',
+        'SQLAlchemy==1.0.8',
+        'mercurial==3.7.3',
+        'numpy==1.9.2',
+        'pycrypto==2.6.1',
+        'Paste==2.0.2',
+        'PasteDeploy==1.5.2',
+        'docutils==0.12',
+        'wchartype==0.1',
+        'repoze.lru==0.6',
+        'Routes==2.2',
+        'WebOb==1.4.1',
+        'WebHelpers==1.3',
+        'Mako==1.0.2',
+        'pytz==2015.4',
+        'Babel==2.0',
+        'Beaker==1.7.0',
+        'dictobj==0.3.1',
+        'nose==1.3.7',
+        'Parsley==1.3',
+        'six==1.9.0',
+        'Whoosh==2.7.4',
+        'Cheetah==2.4.4',
+        'Markdown==2.6.3',
+        'bioblend==0.7.0',
+        'boto==2.38.0',
+        'requests==2.8.1',
+        'requests-toolbelt==0.4.0',
+        'kombu==3.0.30',
+        'amqp==1.4.8',
+        'anyjson==0.3.3',
+        'psutil==4.1.0',
+        'pulsar-galaxy-lib==0.7.0.dev4',
+        'sqlalchemy-migrate==0.10.0',
+        'decorator==4.0.2',
+        'Tempita==0.5.3dev',
+        'sqlparse==0.1.16',
+        'pbr==1.8.0',
+        'svgwrite==1.1.6',
+        'pyparsing==2.1.1',
+        'Fabric==1.10.2',
+        'paramiko==1.15.2',
+        'ecdsa==0.13',
+        'pysam==0.8.4+gx1',
+    ],
+    extras_require={
+        'postgresql': ['psycopg2==2.6.1'],
+    },
     license="Academic Free License 3.0",
     zip_safe=False,
     keywords='galaxy',