diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index 0b90449cd11..4b5403d53c3 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -5,7 +5,7 @@ adal==1.2.7
 aiofiles==0.8.0; python_version >= "3.6" and python_version < "4.0"
 alabaster==0.7.12; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 alembic==1.7.7; python_version >= "3.6"
-amqp==5.1.0; python_version >= "3.7"
+amqp==5.1.1; python_version >= "3.7"
 anyio==3.5.0; python_version >= "3.7" and python_full_version >= "3.6.2"
 apispec==5.1.1; python_version >= "3.6"
 appdirs==1.4.4
@@ -63,9 +63,9 @@ ecdsa==0.17.0; python_version >= "2.6" and python_full_version < "3.0.0" or pyth
 edam-ontology==1.25.2
 fabric3==1.14.post1
 fastapi-utils==0.2.1; python_version >= "3.6" and python_version < "4.0"
-fastapi==0.75.1; python_full_version >= "3.6.1"
+fastapi==0.75.2; python_full_version >= "3.6.1"
 fluent-logger==0.10.0; python_version >= "3.5"
-fonttools==4.31.2; python_version >= "3.7"
+fonttools==4.32.0; python_version >= "3.7"
 fs==2.4.15
 funcsigs==1.0.2
 future==0.18.2; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.3.0")
@@ -82,7 +82,7 @@ humanfriendly==10.0; python_version >= "3.6" and python_full_version < "3.0.0" a
 idna==3.3
 imagesize==1.3.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 importlib-metadata==4.11.3; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7") and python_full_version >= "3.6.2" and (python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6")
-importlib-resources==5.6.0; python_version >= "3.7"
+importlib-resources==5.7.1; python_version >= "3.7"
 iniconfig==1.1.1; python_version >= "3.7"
 isa-rwval==0.10.10
 isodate==0.6.1; python_version >= "3.7" and python_version < "4"
@@ -111,7 +111,7 @@ networkx==2.5; python_version >= "3.6" and python_version < "4"
 nodeenv==1.6.0
 nose==1.3.7
 nosehtml==0.4.6
-numpy==1.21.1; python_version >= "3.7"
+numpy==1.21.6; python_version >= "3.7" and python_version < "3.11"
 oauthlib==3.2.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 outcome==1.1.0; python_version >= "3.7" and python_version < "4.0"
 oyaml==1.0
@@ -123,7 +123,7 @@ pastedeploy==2.1.1
 pathspec==0.9.0; python_full_version >= "3.6.2" and python_version >= "3.6"
 pbr==5.8.1; python_version >= "2.6"
 pillow==9.1.0; python_version >= "3.7"
-platformdirs==2.5.1; python_version >= "3.7" and python_full_version >= "3.6.2"
+platformdirs==2.5.2; python_version >= "3.7" and python_full_version >= "3.6.2"
 pluggy==1.0.0; python_version >= "3.7"
 port-for==0.6.2; python_version >= "3.7"
 prettytable==3.2.0; python_version >= "3.7"
@@ -146,7 +146,7 @@ pykwalify==1.8.0
 pylibmagic==0.2.0; python_version >= "3.7"
 pynacl==1.5.0; python_version >= "3.6"
 pyopenssl==22.0.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.7"
-pyparsing==3.0.7; python_version >= "3.6"
+pyparsing==3.0.8; python_full_version >= "3.6.8"
 pyreadline3==3.4.1; sys_platform == "win32" and python_version >= "3.8" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0")
 pyreadline==2.1; sys_platform == "win32" and python_version < "3.8" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0")
 pyrsistent==0.18.1; python_version >= "3.7"
@@ -157,7 +157,7 @@ pytest-celery==0.0.0
 pytest-cov==3.0.0; python_version >= "3.6"
 pytest-html==3.1.1; python_version >= "3.6"
 pytest-json-report==1.5.0
-pytest-metadata==2.0.0; python_version >= "3.7" and python_version < "4.0"
+pytest-metadata==2.0.1; python_full_version >= "3.7.0" and python_full_version < "3.11.0" and python_version >= "3.6"
 pytest-mock==3.7.0; python_version >= "3.7"
 pytest-postgresql==4.1.1; python_version >= "3.7"
 pytest-shard==0.1.2; python_version >= "3.6"
@@ -186,9 +186,9 @@ rsa==4.8; python_version >= "3.6" and python_version < "4"
 ruamel.yaml.clib==0.2.6; platform_python_implementation == "CPython" and python_version < "3.10" and python_version >= "3.6"
 ruamel.yaml==0.17.17; python_version >= "3.7" and python_version < "4"
 schema-salad==8.2.20220204150214; python_version >= "3.7" and python_version < "4"
-scipy==1.7.3; python_version >= "3.7"
+scipy==1.7.3; python_version >= "3.7" and python_version < "3.11"
 selenium==4.1.3; python_version >= "3.7" and python_version < "4.0"
-setuptools-scm==5.0.2; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
+setuptools-scm==5.0.2; python_version >= "3.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4" and python_version >= "3.7"
 shellescape==3.8.1; python_version >= "3.6" and python_version < "4"
 six==1.16.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.3.0" and python_version >= "3.7" and python_version < "4"
 sniffio==1.2.0; python_version >= "3.7" and python_full_version >= "3.6.2" and python_version < "4.0"
@@ -226,9 +226,9 @@ trio-websocket==0.9.2; python_version >= "3.7" and python_version < "4.0"
 trio==0.20.0; python_version >= "3.7" and python_version < "4.0"
 tuspy==0.2.5
 tuswsgi==0.5.4
-twill==3.0.1
-typed-ast==1.5.2; python_version < "3.8" and implementation_name == "cpython" and python_full_version >= "3.6.2" and python_version >= "3.6"
-typing-extensions==4.1.1; python_version >= "3.6"
+twill==3.0.2
+typed-ast==1.5.3; python_version < "3.8" and implementation_name == "cpython" and python_full_version >= "3.6.2" and python_version >= "3.6"
+typing-extensions==4.2.0; python_version >= "3.7"
 tzlocal==2.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 ubiquerg==0.6.2
 urllib3==1.26.9; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.7"
diff --git a/lib/galaxy/dependencies/pinned-lint-requirements.txt b/lib/galaxy/dependencies/pinned-lint-requirements.txt
index 20c852fb1ed..177c3e8c6d1 100644
--- a/lib/galaxy/dependencies/pinned-lint-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-lint-requirements.txt
@@ -8,20 +8,20 @@ mypy-extensions==0.4.3
 pycodestyle==2.8.0
 pyflakes==2.4.0
 tomli==2.0.1
-typed-ast==1.5.2
-types-bleach==4.1.5
-types-boto==2.49.11
-types-contextvars==2.4.4
-types-cryptography==3.3.19
-types-dataclasses==0.6.4
-types-docutils==0.18.0
-types-Markdown==3.3.12
-types-paramiko==2.8.17
+typed-ast==1.5.3
+types-bleach==5.0.1
+types-boto==2.49.13
+types-contextvars==2.4.5
+types-cryptography==3.3.20
+types-dataclasses==0.6.5
+types-docutils==0.18.2
+types-Markdown==3.3.13
+types-paramiko==2.8.19
 types-pkg-resources==0.1.3
-types-python-dateutil==2.8.10
-types-PyYAML==6.0.5
-types-requests==2.27.16
-types-six==1.16.12
-types-urllib3==1.26.11
-typing_extensions==4.1.1
+types-python-dateutil==2.8.11
+types-PyYAML==6.0.6
+types-requests==2.27.19
+types-six==1.16.15
+types-urllib3==1.26.13
+typing_extensions==4.2.0
 zipp==3.8.0
diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index 9423e9222d5..fcf95edbbdc 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -4,7 +4,7 @@ a2wsgi==1.4.1; python_full_version >= "3.6.2"
 adal==1.2.7
 aiofiles==0.8.0; python_version >= "3.6" and python_version < "4.0"
 alembic==1.7.7; python_version >= "3.6"
-amqp==5.1.0; python_version >= "3.7"
+amqp==5.1.1; python_version >= "3.7"
 anyio==3.5.0; python_version >= "3.7" and python_full_version >= "3.6.2"
 apispec==5.1.1; python_version >= "3.6"
 appdirs==1.4.4
@@ -53,7 +53,7 @@ ecdsa==0.17.0; python_version >= "2.6" and python_full_version < "3.0.0" or pyth
 edam-ontology==1.25.2
 fabric3==1.14.post1
 fastapi-utils==0.2.1; python_version >= "3.6" and python_version < "4.0"
-fastapi==0.75.1; python_full_version >= "3.6.1"
+fastapi==0.75.2; python_full_version >= "3.6.1"
 fs==2.4.15
 funcsigs==1.0.2
 future==0.18.2; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.3.0")
@@ -67,7 +67,7 @@ h5py==3.6.0; python_version >= "3.7"
 humanfriendly==10.0; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0"
 idna==3.3; python_full_version >= "3.6.2" and python_version >= "3.7" and python_version < "4"
 importlib-metadata==4.11.3; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7")
-importlib-resources==5.6.0; python_version >= "3.7"
+importlib-resources==5.7.1; python_version >= "3.7"
 isa-rwval==0.10.10
 isodate==0.6.1; python_version >= "3.7" and python_version < "4"
 jsonref==0.2; python_version >= "3.6"
@@ -87,7 +87,7 @@ mypy-extensions==0.4.3; python_version >= "3.6" and python_version < "4"
 networkx==2.5; python_version >= "3.6" and python_version < "4"
 nodeenv==1.6.0
 nose==1.3.7
-numpy==1.21.1; python_version >= "3.7"
+numpy==1.21.6; python_version >= "3.7" and python_version < "3.11"
 oauthlib==3.2.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 oyaml==1.0
 packaging==21.3; python_version >= "3.6"
@@ -113,7 +113,7 @@ pyjwt==2.3.0; python_version >= "3.6"
 pykwalify==1.8.0
 pylibmagic==0.2.0; python_version >= "3.7"
 pynacl==1.5.0; python_version >= "3.6"
-pyparsing==3.0.7; python_version >= "3.6"
+pyparsing==3.0.8; python_full_version >= "3.6.8"
 pyreadline3==3.4.1; sys_platform == "win32" and python_version >= "3.8" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0")
 pyreadline==2.1; sys_platform == "win32" and python_version < "3.8" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0")
 pyrsistent==0.18.1; python_version >= "3.7"
@@ -158,7 +158,7 @@ tifffile==2021.11.2; python_version >= "3.7"
 tornado==6.1; python_version >= "3.5"
 tqdm==4.64.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 tuswsgi==0.5.4
-typing-extensions==4.1.1; python_version >= "3.6"
+typing-extensions==4.2.0; python_version >= "3.7"
 tzlocal==2.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 ubiquerg==0.6.2
 urllib3==1.26.9; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.6"
diff --git a/pyproject.toml b/pyproject.toml
index caf6f7f34fe..e5ec281fc4e 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -83,7 +83,7 @@ pykwalify = "*"
 pylibmagic = "*"
 pyparsing = "*"
 pysam = "*"
-python = ">=3.7,<4"
+python = ">=3.7,<3.11"  # Keep maximum version strict to appease numpy and scipy
 python-dateutil = "*"
 python-magic = "*"
 python-multipart = "*"  # required to support form parsing in FastAPI/Starlette