diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index b7d512dc724..1ba8403cdfd 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -1,4 +1,4 @@
-a2wsgi==1.9.0 ; python_version >= "3.8" and python_version < "3.12"
+a2wsgi==1.10.0 ; python_version >= "3.8" and python_version < "3.12"
 adal==1.2.7 ; python_version >= "3.8" and python_version < "3.12"
 aiobotocore==2.9.0 ; python_version >= "3.8" and python_version < "3.12"
 aiodataloader==0.4.0 ; python_version >= "3.8" and python_version < "3.12"
@@ -92,7 +92,7 @@ isodate==0.6.1 ; python_version >= "3.8" and python_version < "3.12"
 jinja2==3.1.2 ; python_version >= "3.8" and python_version < "3.12"
 jmespath==1.0.1 ; python_version >= "3.8" and python_version < "3.12"
 jsonref==1.1.0 ; python_version >= "3.8" and python_version < "3.12"
-jsonschema-specifications==2023.11.2 ; python_version >= "3.8" and python_version < "3.12"
+jsonschema-specifications==2023.12.1 ; python_version >= "3.8" and python_version < "3.12"
 jsonschema==4.20.0 ; python_version >= "3.8" and python_version < "3.12"
 kombu==5.3.4 ; python_version >= "3.8" and python_version < "3.12"
 lagom==2.6.0 ; python_version >= "3.8" and python_version < "3.12"
@@ -121,7 +121,7 @@ paramiko==3.4.0 ; python_version >= "3.8" and python_version < "3.12"
 parsley==1.3 ; python_version >= "3.8" and python_version < "3.12"
 paste==3.7.1 ; python_version >= "3.8" and python_version < "3.12"
 pastedeploy==3.1.0 ; python_version >= "3.8" and python_version < "3.12"
-pebble==5.0.5 ; python_version >= "3.8" and python_version < "3.12"
+pebble==5.0.6 ; python_version >= "3.8" and python_version < "3.12"
 pkgutil-resolve-name==1.3.10 ; python_version >= "3.8" and python_version < "3.9"
 promise==2.3 ; python_version >= "3.8" and python_version < "3.12"
 prompt-toolkit==3.0.43 ; python_version >= "3.8" and python_version < "3.12"
@@ -130,7 +130,7 @@ psutil==5.9.7 ; python_version >= "3.8" and python_version < "3.12"
 pulsar-galaxy-lib==0.15.5 ; python_version >= "3.8" and python_version < "3.12"
 pyasn1==0.5.1 ; python_version >= "3.8" and python_version < "3.12"
 pycparser==2.21 ; python_version >= "3.8" and python_version < "3.12"
-pycryptodome==3.19.0 ; python_version >= "3.8" and python_version < "3.12"
+pycryptodome==3.19.1 ; python_version >= "3.8" and python_version < "3.12"
 pydantic-tes==0.1.5 ; python_version >= "3.8" and python_version < "3.12"
 pydantic==1.10.13 ; python_version >= "3.8" and python_version < "3.12"
 pydantic[email]==1.10.13 ; python_version >= "3.8" and python_version < "3.12"
@@ -157,7 +157,7 @@ pyzmq==25.1.2 ; python_version >= "3.8" and python_version < "3.12"
 rdflib==6.3.2 ; python_version >= "3.8" and python_version < "3.12"
 referencing==0.32.0 ; python_version >= "3.8" and python_version < "3.12"
 refgenconf==0.12.2 ; python_version >= "3.8" and python_version < "3.12"
-regex==2023.10.3 ; python_version >= "3.8" and python_version < "3.12"
+regex==2023.12.25 ; python_version >= "3.8" and python_version < "3.12"
 repoze-lru==0.7 ; python_version >= "3.8" and python_version < "3.12"
 requests-oauthlib==1.3.1 ; python_version >= "3.8" and python_version < "3.12"
 requests-toolbelt==1.0.0 ; python_version >= "3.8" and python_version < "3.12"
@@ -166,14 +166,14 @@ requests==2.31.0 ; python_version >= "3.8" and python_version < "3.12"
 rich==13.7.0 ; python_version >= "3.8" and python_version < "3.12"
 rocrate==0.9.0 ; python_version >= "3.8" and python_version < "3.12"
 routes==2.5.1 ; python_version >= "3.8" and python_version < "3.12"
-rpds-py==0.15.2 ; python_version >= "3.8" and python_version < "3.12"
+rpds-py==0.16.2 ; python_version >= "3.8" and python_version < "3.12"
 rsa==4.9 ; python_version >= "3.8" and python_version < "3.12"
 ruamel-yaml-clib==0.2.8 ; platform_python_implementation == "CPython" and python_version < "3.12" and python_version >= "3.8"
 ruamel-yaml==0.18.5 ; python_version >= "3.8" and python_version < "3.12"
 s3fs==2023.12.2 ; python_version >= "3.8" and python_version < "3.12"
 schema-salad==8.5.20231201181309 ; python_version >= "3.8" and python_version < "3.12"
 setuptools-scm==5.0.2 ; python_version >= "3.8" and python_version < "3.12"
-setuptools==69.0.2 ; python_version >= "3.8" and python_version < "3.12"
+setuptools==69.0.3 ; python_version >= "3.8" and python_version < "3.12"
 shellescape==3.8.1 ; python_version >= "3.8" and python_version < "3.12"
 six==1.16.0 ; python_version >= "3.8" and python_version < "3.12"
 sniffio==1.3.0 ; python_version >= "3.8" and python_version < "3.12"
@@ -197,7 +197,7 @@ tqdm==4.66.1 ; python_version >= "3.8" and python_version < "3.12"
 tuspy==1.0.3 ; python_version >= "3.8" and python_version < "3.12"
 tuswsgi==0.5.5 ; python_version >= "3.8" and python_version < "3.12"
 typing-extensions==4.9.0 ; python_version >= "3.8" and python_version < "3.12"
-tzdata==2023.3 ; python_version >= "3.8" and python_version < "3.12"
+tzdata==2023.4 ; python_version >= "3.8" and python_version < "3.12"
 tzlocal==5.2 ; python_version >= "3.8" and python_version < "3.12"
 ubiquerg==0.6.3 ; python_version >= "3.8" and python_version < "3.12"
 urllib3==1.26.18 ; python_version >= "3.8" and python_version < "3.12"