diff --git a/config/job_conf.xml.sample_advanced b/config/job_conf.xml.sample_advanced
index 921cc063aec..361d3693526 100644
--- a/config/job_conf.xml.sample_advanced
+++ b/config/job_conf.xml.sample_advanced
@@ -652,6 +652,30 @@
             <param id="num_jobs">50</param>
             <!-- <param id="job_states">queued</param> -->
         </destination>
+        <destination id="burst_if_queued" runner="dynamic">
+            <!-- Dynamic destinations can be chained together to create more
+            complex rules. In this example, the built-in burst stock rule
+            determines whether to burst, and if so, directs to burst_if_size,
+            a user-defined dynamic destination. This destination in turn will
+            conditionally route it to a remote pulsar node if the input size
+            is below a certain threshold, or route to local if not. -->
+            <param id="type">burst</param>
+            <param id="from_destination_ids">local</param>
+            <param id="to_destination_id">burst_if_size</param>
+            <param id="num_jobs">2</param>
+            <param id="job_states">queued</param>
+        </destination>
+        <destination id="burst_if_size" runner="dynamic">
+            <param id="type">python</param>
+            <param id="function">to_destination_if_size</param>
+            <!-- Also demonstrates a destination level override of the
+            rules_module. This rules_module will take precedence over the
+            plugin level rules module when resolving the dynamic function -->
+            <param id="rules_module">galaxycloudrunner.rules</param>
+            <param id="max_size">1g</param>
+            <param id="to_destination_id">pulsar</param>
+            <param id="fallback_destination_id">local</param>
+        </destination>
         <destination id="docker_dispatch" runner="dynamic">
             <!-- Follow dynamic destination type will send all tool's that
             support docker to static destination defined by
diff --git a/lib/galaxy/jobs/mapper.py b/lib/galaxy/jobs/mapper.py
index 84e0d068258..563309cd483 100644
--- a/lib/galaxy/jobs/mapper.py
+++ b/lib/galaxy/jobs/mapper.py
@@ -205,24 +205,39 @@ class JobRunnerMapper(object):
                 job_destination = self.job_config.get_destination(job_destination_rep)
         return job_destination
 
-    def __cache_job_destination(self, params, raw_job_destination=None):
+    def __determine_job_destination(self, params, raw_job_destination=None):
         if raw_job_destination is None:
             raw_job_destination = self.job_wrapper.tool.get_job_destination(params)
         if raw_job_destination.runner == DYNAMIC_RUNNER_NAME:
             job_destination = self.__handle_dynamic_job_destination(raw_job_destination)
+            log.debug("(%s) Mapped job to destination id: %s", self.job_wrapper.job_id, job_destination.id)
+            # Recursively handle chained dynamic destinations
+            if job_destination.runner == DYNAMIC_RUNNER_NAME:
+                return self.__determine_job_destination(params, raw_job_destination=job_destination)
         else:
             job_destination = raw_job_destination
-        log.debug("(%s) Mapped job to destination id: %s", self.job_wrapper.job_id, job_destination.id)
-        self.cached_job_destination = job_destination
+            log.debug("(%s) Mapped job to destination id: %s", self.job_wrapper.job_id, job_destination.id)
+        return job_destination
+
+    def __cache_job_destination(self, params, raw_job_destination=None):
+        self.cached_job_destination = self.__determine_job_destination(
+            params, raw_job_destination=raw_job_destination)
+        return self.cached_job_destination
 
     def get_job_destination(self, params):
         """
-        Cache the job_destination to avoid recalculation.
+        cached_job_destination is a public property that is sometimes
+        externally set to short-circuit the mapper, such as during resubmits.
+        get_job_destination will respect that and not run the mapper if so.
         """
         if not hasattr(self, 'cached_job_destination'):
-            self.__cache_job_destination(params)
+            return self.__cache_job_destination(params)
         return self.cached_job_destination
 
     def cache_job_destination(self, raw_job_destination):
-        self.__cache_job_destination(None, raw_job_destination=raw_job_destination)
-        return self.cached_job_destination
+        """
+        Force update of cached_job_destination to mapper determined job
+        destination, overwriting any externally set cached_job_destination
+        """
+        return self.__cache_job_destination(
+            None, raw_job_destination=raw_job_destination)
diff --git a/test/integration/chained_dyndest_job_conf.xml b/test/integration/chained_dyndest_job_conf.xml
new file mode 100644
index 00000000000..5fc420259ed
--- /dev/null
+++ b/test/integration/chained_dyndest_job_conf.xml
@@ -0,0 +1,28 @@
+<?xml version="1.0"?>
+<job_conf>
+    <plugins>
+        <plugin id="local" type="runner" load="galaxy.jobs.runners.local:LocalJobRunner" workers="2"/>
+        <plugin id="dynamic" type="runner">
+            <param id="rules_module">integration.chained_dyndest_rules.module1</param>
+        </plugin>
+    </plugins>
+
+    <handlers>
+        <handler id="main"/>
+    </handlers>
+
+    <destinations default="dyn_dest1">
+        <destination id="dyn_dest1" runner="dynamic">
+            <param id="type">python</param>
+            <param id="function">dyndest_chain_1</param>
+        </destination>
+        <destination id="dyn_dest2" runner="dynamic">
+            <param id="type">python</param>
+            <param id="function">dyndest_chain_2</param>
+            <!-- test overriding rules_module at destination level -->
+            <param id="rules_module">integration.chained_dyndest_rules.module2</param>
+            <param id="tmp_dir_prefix">from1</param>
+        </destination>
+    </destinations>
+
+</job_conf>
diff --git a/test/integration/chained_dyndest_rules/__init__.py b/test/integration/chained_dyndest_rules/__init__.py
new file mode 100644
index 00000000000..e69de29bb2d
diff --git a/test/integration/chained_dyndest_rules/module1/__init__.py b/test/integration/chained_dyndest_rules/module1/__init__.py
new file mode 100644
index 00000000000..e69de29bb2d
diff --git a/test/integration/chained_dyndest_rules/module1/rules.py b/test/integration/chained_dyndest_rules/module1/rules.py
new file mode 100644
index 00000000000..8a70a8069e5
--- /dev/null
+++ b/test/integration/chained_dyndest_rules/module1/rules.py
@@ -0,0 +1,15 @@
+def dyndest_chain_1():
+    # Check whether chaining dynamic job destinations work
+    return "dyn_dest2"
+
+
+def dyndest_chain_2():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
+
+
+def dyndest_chain_3():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
diff --git a/test/integration/chained_dyndest_rules/module2/__init__.py b/test/integration/chained_dyndest_rules/module2/__init__.py
new file mode 100644
index 00000000000..e69de29bb2d
diff --git a/test/integration/chained_dyndest_rules/module2/rules.py b/test/integration/chained_dyndest_rules/module2/rules.py
new file mode 100644
index 00000000000..afe0d6dcc0c
--- /dev/null
+++ b/test/integration/chained_dyndest_rules/module2/rules.py
@@ -0,0 +1,23 @@
+from galaxy.jobs import JobDestination
+
+
+def dyndest_chain_1():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
+
+
+def dyndest_chain_2(tmp_dir_prefix):
+    # Chain to yet a third
+    return JobDestination(
+        runner="dynamic",
+        params={'type': 'python',
+                'function': 'dyndest_chain_3',
+                'rules_module': 'integration.chained_dyndest_rules.module3',
+                'tmp_dir_prefix_two': '%sand2' % tmp_dir_prefix})
+
+
+def dyndest_chain_3():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
diff --git a/test/integration/chained_dyndest_rules/module3/__init__.py b/test/integration/chained_dyndest_rules/module3/__init__.py
new file mode 100644
index 00000000000..e69de29bb2d
diff --git a/test/integration/chained_dyndest_rules/module3/rules.py b/test/integration/chained_dyndest_rules/module3/rules.py
new file mode 100644
index 00000000000..72b3f9b68f5
--- /dev/null
+++ b/test/integration/chained_dyndest_rules/module3/rules.py
@@ -0,0 +1,19 @@
+from galaxy.jobs import JobDestination
+
+
+def dyndest_chain_1():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
+
+
+def dyndest_chain_2():
+    # Return an invalid destination as this module's function
+    # should never be called
+    return "invalid_destination"
+
+
+def dyndest_chain_3(tmp_dir_prefix_two):
+    tmp_dir = '$(mktemp %sand3XXXXXXXXXXXX)' % tmp_dir_prefix_two
+    return JobDestination(runner="local",
+                          params={'tmp_dir': tmp_dir})
diff --git a/test/integration/test_chained_dynamic_destinations.py b/test/integration/test_chained_dynamic_destinations.py
new file mode 100644
index 00000000000..2e3b8c8ef23
--- /dev/null
+++ b/test/integration/test_chained_dynamic_destinations.py
@@ -0,0 +1,32 @@
+"""Integration tests for chained dynamic job destinations."""
+
+import os
+import tempfile
+
+from base.populators import (
+    skip_without_tool,
+)
+
+from .test_job_environments import BaseJobEnvironmentIntegrationTestCase
+
+SCRIPT_DIRECTORY = os.path.abspath(os.path.dirname(__file__))
+CHAINED_DYNDESTS_JOB_CONFIG = os.path.join(SCRIPT_DIRECTORY, "chained_dyndest_job_conf.xml")
+
+
+class ChainedDynamicDestinationIntegrationTestCase(BaseJobEnvironmentIntegrationTestCase):
+
+    @classmethod
+    def handle_galaxy_config_kwds(cls, config):
+        cls.jobs_directory = tempfile.mkdtemp()
+        config["jobs_directory"] = cls.jobs_directory
+        config["job_config_file"] = CHAINED_DYNDESTS_JOB_CONFIG
+
+    @skip_without_tool("job_environment_default")
+    def test_default_environment_1801(self):
+        job_env = self._run_and_get_environment_properties()
+
+        # Since dynamic destinations compute final tmp_dir parameter to be
+        # $(mktemp from1and2and3XXXXXXXXXXXX), tmpdir should start
+        # with from1and2and3.
+        basename = os.path.basename(job_env.tmp)
+        assert basename.startswith("from1and2and3"), job_env.tmp
diff --git a/test/unit/jobs/test_mapper.py b/test/unit/jobs/test_mapper.py
index 30e02a77dc4..9f0e70d6bbc 100644
--- a/test/unit/jobs/test_mapper.py
+++ b/test/unit/jobs/test_mapper.py
@@ -36,6 +36,12 @@ def test_dynamic_mapping():
     assert mapper.job_config.rule_response == "local_runner"
 
 
+def test_chained_dynamic_mapping():
+    mapper = __mapper(__dynamic_destination(dict(function="dynamic_chain_1")))
+    assert mapper.get_job_destination({}) is DYNAMICALLY_GENERATED_DESTINATION
+    assert mapper.job_config.rule_response == "final_destination"
+
+
 def test_dynamic_mapping_priorities():
     mapper = __mapper(__dynamic_destination(dict(function="tophat")))
     assert mapper.get_job_destination({}) is DYNAMICALLY_GENERATED_DESTINATION
@@ -97,6 +103,23 @@ def test_dynamic_mapping_rule_module_override():
     assert mapper.job_config.rule_response == "new_rules_package"
 
 
+def test_dynamic_mapping_externally_set_job_destination():
+    mapper = __mapper(__dynamic_destination(dict(function="upload")))
+    # Initially, the mapper should not have a cached destination
+    assert not hasattr(mapper, 'cached_job_destination')
+    # Overwrite with an externally set job destination
+    manually_set_destination = JobDestination(runner="dynamic")
+    mapper.cached_job_destination = manually_set_destination
+    destination = mapper.get_job_destination({})
+    assert destination == manually_set_destination
+    assert mapper.cached_job_destination == manually_set_destination
+    # Force overwrite with mapper determined destination
+    mapper.cache_job_destination(None)
+    assert mapper.cached_job_destination is not None
+    assert mapper.cached_job_destination != manually_set_destination
+    assert mapper.job_config.rule_response == "local_runner"
+
+
 def __assert_mapper_errors_with_message(mapper, message):
     exception = None
     try:
diff --git a/test/unit/jobs/test_rules/10_site.py b/test/unit/jobs/test_rules/10_site.py
index a3578dac359..0712df11d87 100644
--- a/test/unit/jobs/test_rules/10_site.py
+++ b/test/unit/jobs/test_rules/10_site.py
@@ -1,3 +1,4 @@
+from galaxy.jobs import JobDestination
 
 
 def upload():
@@ -15,6 +16,20 @@ def tool1():
     return 'tool1_dest_id'
 
 
+def dynamic_chain_1():
+    # Check whether chaining dynamic job destinations work
+    return JobDestination(runner="dynamic",
+                          params={'type': 'python',
+                                  'function': 'dynamic_chain_2',
+                                  'test_param': 'my_test_param'})
+
+
+def dynamic_chain_2(test_param):
+    # Check whether chaining dynamic job destinations work
+    assert test_param == "my_test_param"
+    return "final_destination"
+
+
 def check_rule_params(
     job_id,
     tool,