diff --git a/client/src/components/DatasetInformation/DatasetAttributes.vue b/client/src/components/DatasetInformation/DatasetAttributes.vue
index dd942966dd0..73874c5f601 100644
--- a/client/src/components/DatasetInformation/DatasetAttributes.vue
+++ b/client/src/components/DatasetInformation/DatasetAttributes.vue
@@ -20,12 +20,16 @@
                                 @click="submit('attribute', 'attributes')">
                                 <font-awesome-icon icon="save" class="mr-1" />{{ "Save" | l }}
                             </b-button>
-                            <b-button @click="submit('attribute', 'autodetect')">
+                            <b-button v-if="!result['metadata_disable']" @click="submit('attribute', 'autodetect')">
                                 <font-awesome-icon icon="redo" class="mr-1" />{{ "Auto-detect" | l }}
                             </b-button>
                         </div>
                     </b-tab>
-                    <b-tab v-if="!result['conversion_disable'] || !result['datatype_disable']">
+                    <b-tab
+                        v-if="
+                            (!result['conversion_disable'] || !result['datatype_disable']) &&
+                            !result['metadata_disable']
+                        ">
                         <template v-slot:title>
                             <span v-if="!result['conversion_disable']">
                                 <font-awesome-icon icon="cog" class="mr-1" />{{ "Convert" | l }}
diff --git a/lib/galaxy/webapps/galaxy/controllers/dataset.py b/lib/galaxy/webapps/galaxy/controllers/dataset.py
index 0473f7d2a1f..fe1578907b9 100644
--- a/lib/galaxy/webapps/galaxy/controllers/dataset.py
+++ b/lib/galaxy/webapps/galaxy/controllers/dataset.py
@@ -291,6 +291,10 @@ class DatasetInterface(BaseUIController, UsesAnnotations, UsesItemRatings, UsesE
             if data.missing_meta():
                 message = 'Required metadata values are missing. Some of these values may not be editable by the user. Selecting "Auto-detect" will attempt to fix these values.'
                 status = "warning"
+            metadata_disable = data.state not in [
+                trans.model.Dataset.states.OK,
+                trans.model.Dataset.states.FAILED_METADATA,
+            ]
             # datatype conversion
             conversion_options = [
                 (f"{convert_id} (using '{convert_name}')", convert_id)
@@ -369,6 +373,7 @@ class DatasetInterface(BaseUIController, UsesAnnotations, UsesItemRatings, UsesE
                 "message": message,
                 "status": status,
                 "dataset_id": dataset_id,
+                "metadata_disable": metadata_disable,
                 "attribute_inputs": attribute_inputs,
                 "conversion_inputs": conversion_inputs,
                 "conversion_disable": conversion_disable,