diff --git a/.github/workflows/dependencies.yaml b/.github/workflows/dependencies.yaml
index 8cd1dd04051..fbb6acbb966 100644
--- a/.github/workflows/dependencies.yaml
+++ b/.github/workflows/dependencies.yaml
@@ -27,6 +27,7 @@ jobs:
       - name: Create pull request
         uses: peter-evans/create-pull-request@v3
         with:
+          author: galaxybot <galaxybot@users.noreply.github.com>
           token: ${{ secrets.GALAXYBOT_PAT }}
           commit-message: Update Python dependencies
           branch: dev_auto_update_dependencies
diff --git a/lib/galaxy/dependencies/dev-requirements.txt b/lib/galaxy/dependencies/dev-requirements.txt
index 769efd4aa9a..79650ee0fb7 100644
--- a/lib/galaxy/dependencies/dev-requirements.txt
+++ b/lib/galaxy/dependencies/dev-requirements.txt
@@ -3,15 +3,15 @@
 adal==1.2.7
 aiofiles==0.8.0; python_version >= "3.6" and python_version < "4.0"
 alabaster==0.7.12; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
-amqp==5.0.6; python_version >= "3.7"
-anyio==3.4.0; python_full_version >= "3.6.2" and python_version >= "3.6"
+amqp==5.0.9; python_version >= "3.7"
+anyio==3.4.0; python_version >= "3.7" and python_full_version >= "3.6.2"
 appdirs==1.4.4
 argcomplete==1.12.3; python_version >= "3.6" and python_version < "4"
 asgiref==3.4.1; python_version >= "3.6"
 async-generator==1.10; python_version >= "3.7" and python_version < "4.0"
 atomicwrites==1.4.0; python_version >= "3.7" and python_full_version < "3.0.0" and sys_platform == "win32" or sys_platform == "win32" and python_version >= "3.7" and python_full_version >= "3.4.0"
 attmap==0.13.2
-attrs==21.2.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4.0" or python_full_version >= "3.5.0" and python_version >= "3.7" and python_version < "4.0"
+attrs==21.4.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4.0" or python_full_version >= "3.5.0" and python_version >= "3.7" and python_version < "4.0"
 babel==2.9.1; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 bagit-profile==1.3.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 bagit==1.8.1; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.5.0" and python_version < "4" and python_version >= "3.6"
@@ -24,10 +24,10 @@ black==21.12b0; python_full_version >= "3.6.2" and python_version >= "3.6"
 bleach==4.1.0; python_version >= "3.6"
 boltons==21.0.0
 boto==2.49.0
-bx-python==0.8.12; python_version >= "3.6"
+bx-python==0.8.13; python_version >= "3.7"
 cachecontrol==0.12.10; python_version >= "3.6" and python_version < "4"
 cached-property==1.5.2; python_version < "3.8" and python_version >= "3.7"
-celery==5.2.1; python_version >= "3.7"
+celery==5.2.3; python_version >= "3.7"
 certifi==2021.10.8; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.7"
 cffi==1.15.0
 charset-normalizer==2.0.9; python_full_version >= "3.6.0" and python_version >= "3.6" and python_version < "4"
@@ -43,7 +43,7 @@ colorama==0.4.4; sys_platform == "win32" and python_version >= "3.7" and python_
 coloredlogs==15.0.1; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0"
 commonmark==0.9.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
 coverage==6.2; python_version >= "3.6"
-cryptography==36.0.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.7"
+cryptography==36.0.1; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.7"
 cwltest==2.2.20210901154959; python_version >= "3.6" and python_version < "4"
 cwltool==3.1.20211107152837; python_version >= "3.6" and python_version < "4"
 darker==1.3.2; python_version >= "3.6"
@@ -72,20 +72,20 @@ h5py==3.6.0; python_version >= "3.7"
 httpcore==0.14.3; python_version >= "3.6"
 httpx==0.21.1; python_version >= "3.6"
 humanfriendly==10.0; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0"
-idna==3.3; python_version >= "3.7" and python_version < "4.0" and python_full_version >= "3.6.2"
+idna==3.3
 imagesize==1.3.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
-importlib-metadata==4.8.2; python_version == "3.7" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.6")
+importlib-metadata==4.10.0; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7")
 importlib-resources==5.4.0; python_version < "3.9" and python_version >= "3.7"
 iniconfig==1.1.1; python_version >= "3.7"
 isa-rwval==0.10.10
-isodate==0.6.0; python_version >= "3.7" and python_version < "4"
+isodate==0.6.1; python_version >= "3.7" and python_version < "4"
 jinja2==3.0.3; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
-jsonschema==4.2.1; python_version >= "3.7"
+jsonschema==4.3.2; python_version >= "3.7"
 junit-xml==1.9; python_version >= "3.6" and python_version < "4"
-kombu==5.2.2; python_version >= "3.7"
+kombu==5.2.3; python_version >= "3.7"
 lagom==1.7.0; python_version >= "3.6" and python_version < "4.0"
 lockfile==0.12.2; python_version >= "3.6" and python_version < "4"
-lxml==4.6.4; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
+lxml==4.7.1; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
 mako==1.1.6; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 markdown-it-reporter==0.0.2
 markdown==3.3.6; python_version >= "3.6"
@@ -111,24 +111,24 @@ paste==3.5.0
 pastedeploy==2.1.1
 pathspec==0.9.0; python_full_version >= "3.6.2" and python_version >= "3.6"
 pbr==5.8.0; python_version >= "2.6"
-platformdirs==2.4.0; python_full_version >= "3.6.2" and python_version >= "3.6"
+platformdirs==2.4.1; python_full_version >= "3.6.2" and python_version >= "3.7"
 pluggy==1.0.0; python_version >= "3.7"
 port-for==0.6.1; python_version >= "3.7"
-prettytable==2.4.0; python_version >= "3.6"
+prettytable==2.5.0; python_version >= "3.6"
 prompt-toolkit==3.0.24; python_full_version >= "3.6.2" and python_version >= "3.7"
 prov==1.5.1; python_version >= "3.6" and python_version < "4"
-psutil==5.8.0; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
+psutil==5.9.0; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 pulsar-galaxy-lib==0.14.13
 py==1.11.0; python_version >= "3.7" and python_full_version < "3.0.0" and implementation_name == "pypy" or python_full_version >= "3.5.0" and python_version >= "3.7" and implementation_name == "pypy"
 pyasn1==0.4.8; python_version >= "3.6" and python_version < "4"
 pycparser==2.21
 pycryptodome==3.12.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
-pydantic==1.8.2; python_version >= "3.6" and python_version < "4.0" and python_full_version >= "3.6.1"
+pydantic==1.9.0; python_version >= "3.6" and python_version < "4.0" and python_full_version >= "3.6.1"
 pydot==1.4.2; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.4.0"
 pyeventsystem==0.1.0
 pyfaidx==0.6.3.1
 pygithub==1.55; python_version >= "3.6"
-pygments==2.10.0; python_full_version >= "3.6.2" and python_full_version < "4.0.0" and python_version >= "3.6" and (python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6")
+pygments==2.11.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0" and python_version >= "3.6" and (python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6")
 pyjwt==2.3.0; python_version >= "3.6"
 pykwalify==1.8.0
 pynacl==1.4.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
@@ -145,7 +145,7 @@ pytest-html==3.1.1; python_version >= "3.6"
 pytest-json-report==1.4.1
 pytest-metadata==1.11.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.6.0" and python_version >= "3.6"
 pytest-mock==3.6.1; python_version >= "3.6"
-pytest-postgresql==4.0.0; python_version >= "3.7"
+pytest-postgresql==4.1.0; python_version >= "3.7"
 pytest-pythonpath==0.7.3
 pytest-shard==0.1.2; python_version >= "3.6"
 pytest==6.2.5; python_version >= "3.6"
@@ -167,23 +167,23 @@ requests-toolbelt==0.9.1; python_version >= "3.6"
 requests==2.26.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
 responses==0.16.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
 rfc3986==1.5.0; python_version >= "3.6"
-rich==10.15.2; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
+rich==10.16.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
 routes==2.5.1
 rsa==4.8; python_version >= "3.6" and python_version < "4"
 ruamel.yaml.clib==0.2.6; platform_python_implementation == "CPython" and python_version < "3.10" and python_version >= "3.6"
 ruamel.yaml==0.17.17; python_version >= "3.6" and python_version < "4"
-schema-salad==8.2.20211116214159; python_version >= "3.6" and python_version < "4"
+schema-salad==8.2.20211222191353; python_version >= "3.6" and python_version < "4"
 selenium==4.1.0; python_version >= "3.7" and python_version < "4.0"
 setuptools-scm==5.0.2; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 shellescape==3.8.1; python_version >= "3.6" and python_version < "4"
 six==1.16.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.3.0")
-sniffio==1.2.0; python_version >= "3.7" and python_version < "4.0" and python_full_version >= "3.6.2"
+sniffio==1.2.0; python_version >= "3.7" and python_full_version >= "3.6.2" and python_version < "4.0"
 snowballstemmer==2.2.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 social-auth-core==4.0.3
 sortedcontainers==2.4.0
 sphinx-markdown-tables==0.0.15
 sphinx-rtd-theme==1.0.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
-sphinx==4.3.1; python_version >= "3.6"
+sphinx==4.3.2; python_version >= "3.6"
 sphinxcontrib-applehelp==1.0.2; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 sphinxcontrib-devhelp==1.0.2; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 sphinxcontrib-htmlhelp==2.0.0; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
@@ -191,7 +191,7 @@ sphinxcontrib-jsmath==1.0.1; python_version >= "3.6" and python_full_version < "
 sphinxcontrib-qthelp==1.0.3; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 sphinxcontrib-serializinghtml==1.1.5; python_version >= "3.6" and python_full_version < "3.0.0" or python_full_version >= "3.4.0" and python_version >= "3.6"
 sqlalchemy-migrate==0.13.0
-sqlalchemy==1.4.28; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
+sqlalchemy==1.4.29; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
 sqlitedict==1.7.0
 sqlparse==0.4.2; python_version >= "3.5"
 starlette-context==0.3.3; python_version >= "3.7"
@@ -204,7 +204,7 @@ testfixtures==6.18.3
 tifffile==2021.11.2; python_version >= "3.7"
 tinydb==4.5.0; python_version >= "3.5" and python_version < "4.0"
 toml==0.10.2; python_version >= "3.7" and python_full_version < "3.0.0" or python_full_version >= "3.3.0" and python_version >= "3.7"
-tomli==1.2.2; python_full_version >= "3.6.2" and python_version >= "3.6"
+tomli==1.2.3; python_full_version >= "3.6.2" and python_version >= "3.6"
 tornado==6.1; python_version >= "3.5"
 tqdm==4.62.3; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 trio-websocket==0.9.2; python_version >= "3.7" and python_version < "4.0"
@@ -228,5 +228,5 @@ wrapt==1.13.3; python_version >= "3.6" and python_full_version < "3.0.0" or pyth
 wsproto==1.0.0; python_version >= "3.7" and python_version < "4.0" and python_full_version >= "3.6.1"
 xmlrunner==1.7.7
 yacman==0.8.4
-zipp==3.6.0; python_version == "3.7" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.6")
+zipp==3.7.0; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7")
 zipstream-new==1.1.8
diff --git a/lib/galaxy/dependencies/pinned-lint-requirements.txt b/lib/galaxy/dependencies/pinned-lint-requirements.txt
index 6fd5258713f..3f01031d450 100644
--- a/lib/galaxy/dependencies/pinned-lint-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-lint-requirements.txt
@@ -1,4 +1,4 @@
-attrs==21.2.0
+attrs==21.4.0
 flake8==4.0.1
 flake8-bugbear==21.11.29
 flake8-import-order==0.18.1
@@ -10,20 +10,20 @@ pycodestyle==2.8.0
 pyflakes==2.4.0
 toml==0.10.2
 typed-ast==1.4.3
-types-bleach==4.1.1
-types-boto==2.49.2
+types-bleach==4.1.2
+types-boto==2.49.3
 types-contextvars==2.4.0
-types-cryptography==3.3.9
-types-dataclasses==0.6.1
-types-docutils==0.17.1
+types-cryptography==3.3.10
+types-dataclasses==0.6.2
+types-docutils==0.17.2
 types-enum34==1.1.1
 types-ipaddress==1.0.1
-types-Markdown==3.3.9
-types-paramiko==2.8.4
+types-Markdown==3.3.10
+types-paramiko==2.8.6
 types-pkg-resources==0.1.3
-types-python-dateutil==2.8.3
+types-python-dateutil==2.8.4
 types-PyYAML==6.0.1
-types-requests==2.26.1
-types-six==1.16.3
+types-requests==2.26.3
+types-six==1.16.6
 typing_extensions==4.0.1
-zipp==3.6.0
+zipp==3.7.0
diff --git a/lib/galaxy/dependencies/pinned-requirements.txt b/lib/galaxy/dependencies/pinned-requirements.txt
index 8251a210f84..5b743c333be 100644
--- a/lib/galaxy/dependencies/pinned-requirements.txt
+++ b/lib/galaxy/dependencies/pinned-requirements.txt
@@ -2,12 +2,12 @@
 
 adal==1.2.7
 aiofiles==0.8.0; python_version >= "3.6" and python_version < "4.0"
-amqp==5.0.6; python_version >= "3.7"
+amqp==5.0.9; python_version >= "3.7"
 appdirs==1.4.4
 argcomplete==1.12.3; python_version >= "3.6" and python_version < "4"
 asgiref==3.4.1; python_version >= "3.6"
 attmap==0.13.2
-attrs==21.2.0; python_version >= "3.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version >= "3.7"
+attrs==21.4.0; python_version >= "3.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version >= "3.7"
 babel==2.9.1; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 bagit-profile==1.3.1; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 bagit==1.8.1; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.5.0" and python_version < "4" and python_version >= "3.6"
@@ -19,10 +19,10 @@ bioblend==0.16.0; python_version >= "3.6"
 bleach==4.1.0; python_version >= "3.6"
 boltons==21.0.0
 boto==2.49.0
-bx-python==0.8.12; python_version >= "3.6"
+bx-python==0.8.13; python_version >= "3.7"
 cachecontrol==0.12.10; python_version >= "3.6" and python_version < "4"
 cached-property==1.5.2; python_version < "3.8" and python_version >= "3.7"
-celery==5.2.1; python_version >= "3.7"
+celery==5.2.3; python_version >= "3.7"
 certifi==2021.10.8; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.6"
 cffi==1.15.0; implementation_name == "pypy" and python_version >= "3.6" and (python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0")
 charset-normalizer==2.0.9; python_full_version >= "3.6.0" and python_version >= "3.6" and python_version < "4"
@@ -37,7 +37,7 @@ cloudbridge==3.0.0
 colorama==0.4.4; platform_system == "Windows" and python_version >= "3.7" and python_full_version >= "3.6.2" and python_full_version < "4.0.0" and (python_version >= "2.7" and python_full_version < "3.0.0" and platform_system == "Windows" or python_full_version >= "3.5.0" and platform_system == "Windows")
 coloredlogs==15.0.1; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0"
 commonmark==0.9.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
-cryptography==36.0.0; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.6"
+cryptography==36.0.1; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version < "4" and python_version >= "3.6"
 cwltool==3.1.20211107152837; python_version >= "3.6" and python_version < "4"
 decorator==5.1.0; python_version >= "3.6" and python_version < "4"
 defusedxml==0.7.1; python_version >= "3.0" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version >= "3.0"
@@ -59,16 +59,16 @@ gxformat2==0.15.0
 h11==0.12.0; python_version >= "3.6"
 h5py==3.6.0; python_version >= "3.7"
 humanfriendly==10.0; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.5.0"
-idna==3.3; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.6.0" and python_version >= "3.6" and python_version < "4"
-importlib-metadata==4.8.2; python_version == "3.7" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.6")
+idna==3.3; python_full_version >= "3.6.2" and python_version >= "3.7" and python_version < "4"
+importlib-metadata==4.10.0; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7")
 importlib-resources==5.4.0; python_version < "3.9" and python_version >= "3.7"
 isa-rwval==0.10.10
-isodate==0.6.0; python_version >= "3.7" and python_version < "4"
-jsonschema==4.2.1; python_version >= "3.7"
-kombu==5.2.2; python_version >= "3.7"
+isodate==0.6.1; python_version >= "3.7" and python_version < "4"
+jsonschema==4.3.2; python_version >= "3.7"
+kombu==5.2.3; python_version >= "3.7"
 lagom==1.7.0; python_version >= "3.6" and python_version < "4.0"
 lockfile==0.12.2; python_version >= "3.6" and python_version < "4"
-lxml==4.6.4; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
+lxml==4.7.1; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
 mako==1.1.6; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 markdown==3.3.6; python_version >= "3.6"
 markupsafe==2.0.1; python_version >= "3.6"
@@ -91,17 +91,17 @@ pastedeploy==2.1.1
 pbr==5.8.0; python_version >= "2.6"
 prompt-toolkit==3.0.24; python_full_version >= "3.6.2" and python_version >= "3.7"
 prov==1.5.1; python_version >= "3.6" and python_version < "4"
-psutil==5.8.0; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
+psutil==5.9.0; (python_version >= "2.6" and python_full_version < "3.0.0") or (python_full_version >= "3.4.0")
 pulsar-galaxy-lib==0.14.13
 py==1.11.0; python_version >= "3.6" and python_full_version < "3.0.0" and implementation_name == "pypy" or implementation_name == "pypy" and python_version >= "3.6" and python_full_version >= "3.5.0"
 pyasn1==0.4.8; python_version >= "3.6" and python_version < "4"
 pycparser==2.21; python_version >= "3.6" and python_full_version < "3.0.0" and implementation_name == "pypy" and (python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0") or implementation_name == "pypy" and python_version >= "3.6" and (python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0") and python_full_version >= "3.4.0"
 pycryptodome==3.12.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.5.0")
-pydantic==1.8.2; python_version >= "3.6" and python_version < "4.0" and python_full_version >= "3.6.1"
+pydantic==1.9.0; python_version >= "3.6" and python_version < "4.0" and python_full_version >= "3.6.1"
 pydot==1.4.2; python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "4" or python_version >= "3.6" and python_version < "4" and python_full_version >= "3.4.0"
 pyeventsystem==0.1.0
 pyfaidx==0.6.3.1
-pygments==2.10.0; python_full_version >= "3.6.2" and python_full_version < "4.0.0" and python_version >= "3.5"
+pygments==2.11.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0" and python_version >= "3.5"
 pyjwt==2.3.0; python_version >= "3.6"
 pykwalify==1.8.0
 pynacl==1.4.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
@@ -124,19 +124,19 @@ repoze.lru==0.7
 requests-oauthlib==1.3.0; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.4.0"
 requests-toolbelt==0.9.1; python_version >= "3.6"
 requests==2.26.0; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
-rich==10.15.2; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
+rich==10.16.1; python_full_version >= "3.6.2" and python_full_version < "4.0.0"
 routes==2.5.1
 rsa==4.8; python_version >= "3.6" and python_version < "4"
 ruamel.yaml.clib==0.2.6; platform_python_implementation == "CPython" and python_version < "3.10" and python_version >= "3.6"
 ruamel.yaml==0.17.17; python_version >= "3.6" and python_version < "4"
-schema-salad==8.2.20211116214159; python_version >= "3.6" and python_version < "4"
+schema-salad==8.2.20211222191353; python_version >= "3.6" and python_version < "4"
 setuptools-scm==5.0.2; python_version >= "2.7" and python_full_version < "3.0.0" or python_full_version >= "3.5.0" and python_version < "4"
 shellescape==3.8.1; python_version >= "3.6" and python_version < "4"
 six==1.16.0; python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "4" or python_full_version >= "3.4.0" and python_version >= "3.7" and python_version < "4"
 social-auth-core==4.0.3
 sortedcontainers==2.4.0
 sqlalchemy-migrate==0.13.0
-sqlalchemy==1.4.28; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
+sqlalchemy==1.4.29; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.6.0")
 sqlitedict==1.7.0
 sqlparse==0.4.2; python_version >= "3.5"
 starlette-context==0.3.3; python_version >= "3.7"
@@ -159,5 +159,5 @@ webencodings==0.5.1; python_version >= "3.6"
 webob==1.8.7; (python_version >= "2.7" and python_full_version < "3.0.0") or (python_full_version >= "3.3.0")
 whoosh==2.7.4
 yacman==0.8.4
-zipp==3.6.0; python_version == "3.7" and (python_version >= "3.6" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.6")
+zipp==3.7.0; python_version == "3.7" and (python_version >= "3.7" and python_full_version < "3.0.0" and python_version < "3.8" or python_full_version >= "3.6.0" and python_version < "3.8" and python_version >= "3.7")
 zipstream-new==1.1.8
diff --git a/packages/app/requirements.txt b/packages/app/requirements.txt
index 7b73ec92c8b..7468b5a2c04 100644
--- a/packages/app/requirements.txt
+++ b/packages/app/requirements.txt
@@ -15,7 +15,9 @@ kombu
 lagom
 Mako
 Markdown
+paramiko!=2.9.0,!=2.9.1
 pulsar-galaxy-lib>=0.14.13
+pydantic
 pykwalify
 refgenconf>=0.12.0
 sqlitedict
diff --git a/packages/web_framework/requirements.txt b/packages/web_framework/requirements.txt
index 2aabc3e555b..c60ad2b07fc 100644
--- a/packages/web_framework/requirements.txt
+++ b/packages/web_framework/requirements.txt
@@ -4,7 +4,7 @@ galaxy-util
 galaxy-web-stack
 MarkupSafe
 paste
-pydantic<1.8
+pydantic
 requests
 Routes
 SQLAlchemy>=1.4.25,<2
diff --git a/packages/webapps/requirements.txt b/packages/webapps/requirements.txt
index 8392e9eb703..0e18dbbfb16 100644
--- a/packages/webapps/requirements.txt
+++ b/packages/webapps/requirements.txt
@@ -1,8 +1,9 @@
 galaxy-app
 Cheetah3
-fastapi>=0.68.2,!=0.69.0,!=0.70.0
+fastapi>=0.68.2,!=0.69.0,!=0.70.0,!=0.70.1
 fastapi-utils
 Mako
+pydantic
 python-multipart  # required to support form parsing in FastAPI/Starlette
 starlette
 typing-extensions
diff --git a/pyproject.toml b/pyproject.toml
index d389aab2e31..690beb6b130 100644
--- a/pyproject.toml
+++ b/pyproject.toml
@@ -33,7 +33,7 @@ dictobj = "*"
 docutils = "!=0.17, !=0.17.1"
 edam-ontology = "*"
 Fabric3 = "*"
-fastapi = ">=0.68.2, !=0.69.0, !=0.70.0"  # https://github.com/tiangolo/fastapi/issues/4041
+fastapi = ">=0.68.2, !=0.69.0, !=0.70.0, !=0.70.1"  # https://github.com/tiangolo/fastapi/issues/4041
 fastapi-utils = "*"
 fs = "*"
 future = "*"
@@ -51,12 +51,13 @@ mrcfile = "*"
 nodeenv = "*"
 nose = "*"
 numpy = "*"
-paramiko = "*"
+paramiko = "!=2.9.0, !=2.9.1"  # https://github.com/paramiko/paramiko/issues/1961
 Parsley = "*"
 Paste = "*"
 psutil = "*"
 pulsar-galaxy-lib = ">=0.14.13"
 pycryptodome = "*"
+pydantic = "*"
 pykwalify = "*"
 pyparsing = "*"
 pysam = "*"