diff --git a/lib/galaxy/web/stack/__init__.py b/lib/galaxy/web/stack/__init__.py
index 44a58b882d4..ab7976b2526 100644
--- a/lib/galaxy/web/stack/__init__.py
+++ b/lib/galaxy/web/stack/__init__.py
@@ -255,7 +255,7 @@ class UWSGIApplicationStack(MessageApplicationStack):
         # Does a generalized `is_worker` attribute make sense? Hard to say w/o other stack paradigms.
         if self._is_mule and self._farm_name:
             # used by main.py to send a shutdown message on termination
-            os.environ['_GALAXY_UWSGI_FARM_NAME'] = self._farm_name
+            os.environ['_GALAXY_UWSGI_FARM_NAMES'] = ','.join(self._farms)
         super(UWSGIApplicationStack, self).start()
 
     def has_pool(self, pool_name):
diff --git a/scripts/galaxy-main b/scripts/galaxy-main
index b42b4e5225f..9cb5b7da345 100755
--- a/scripts/galaxy-main
+++ b/scripts/galaxy-main
@@ -62,7 +62,7 @@ DEFAULT_VERBOSE = True
 DESCRIPTION = "Daemonized entry point for Galaxy."
 
 SHUTDOWN_MSG = '__SHUTDOWN__'
-UWSGI_FARM_VAR = '_GALAXY_UWSGI_FARM_NAME'
+UWSGI_FARMS_VAR = '_GALAXY_UWSGI_FARM_NAMES'
 
 
 exit = threading.Event()
@@ -103,9 +103,10 @@ def load_galaxy_app(
 def handle_signal(signum, frame):
     log.info('Received signal %d, exiting', signum)
     if uwsgi and 'mule_id' in dir(uwsgi) and uwsgi.mule_id() > 0:
-        farm = os.environ.get(UWSGI_FARM_VAR, None)
-        if farm:
-            uwsgi.farm_msg(farm, SHUTDOWN_MSG)
+        farms = os.environ.get(UWSGI_FARMS_VAR, None)
+        if farms:
+            for farm in farms.split(','):
+                uwsgi.farm_msg(farm, SHUTDOWN_MSG)
         else:
             uwsgi.mule_msg(SHUTDOWN_MSG, uwsgi.mule_id())
     exit.set()