diff --git a/client/src/components/FilesDialog/FilesDialog.vue b/client/src/components/FilesDialog/FilesDialog.vue
index 4d05e124f50..0a5ff68ec96 100644
--- a/client/src/components/FilesDialog/FilesDialog.vue
+++ b/client/src/components/FilesDialog/FilesDialog.vue
@@ -30,7 +30,7 @@
             <b-btn
                 v-if="multiple"
                 size="sm"
-                class="float-right ml-1"
+                class="float-right ml-1 file-dialog-modal-ok"
                 variant="primary"
                 @click="finalize"
                 :disabled="!hasValue"
diff --git a/lib/galaxy/selenium/navigation.yml b/lib/galaxy/selenium/navigation.yml
index 06e72921e4b..58140977586 100644
--- a/lib/galaxy/selenium/navigation.yml
+++ b/lib/galaxy/selenium/navigation.yml
@@ -679,6 +679,10 @@ upload:
     rule_dataset_selector_row:
       selector: '.selection-dialog-modal [aria-rowindex="${rowindex}"]'
     build_btn: '#rule-based #btn-build'
+    file_source_selector:
+      type: xpath
+      selector: '//span[contains(@title, "${path}")]'
+    file_dialog_ok: '.file-dialog-modal-ok'
 
 rule_builder:
   selectors:
diff --git a/test/__init__.py b/test/__init__.py
new file mode 100644
index 00000000000..e69de29bb2d
diff --git a/test/integration/test_remote_files_posix.py b/test/integration/test_remote_files_posix.py
index f94ef24f4b7..7cbffb74876 100644
--- a/test/integration/test_remote_files_posix.py
+++ b/test/integration/test_remote_files_posix.py
@@ -37,7 +37,7 @@ def create_file_source_config_file_on(temp_dir, root_dir):
     return file_path
 
 
-class PosixFileSourceIntegrationTestCase(integration_util.IntegrationTestCase):
+class PosixFileSourceSetup:
 
     @classmethod
     def handle_galaxy_config_kwds(cls, config):
@@ -53,10 +53,32 @@ class PosixFileSourceIntegrationTestCase(integration_util.IntegrationTestCase):
         config["library_import_dir"] = None
         config["user_library_import_dir"] = None
 
+    def _write_file_fixtures(self):
+        root = self.root_dir
+        if os.path.exists(root):
+            shutil.rmtree(root)
+        os.mkdir(root)
+
+        with open(os.path.join(root, "a"), "w") as f:
+            f.write("a\n")
+
+        subdir1 = os.path.join(root, "subdir1")
+        os.mkdir(subdir1)
+        with open(os.path.join(subdir1, "b"), "w") as f:
+            f.write("b\n")
+
+        return root
+
+    def setUp(self):
+        super().setUp()
+        self._write_file_fixtures()
+
+
+class PosixFileSourceIntegrationTestCase(PosixFileSourceSetup, integration_util.IntegrationTestCase):
+
     def setUp(self):
         super().setUp()
         self.dataset_populator = DatasetPopulator(self.galaxy_interactor)
-        self._write_file_fixtures()
 
     def test_plugin_config(self):
         plugin_config_response = self.galaxy_interactor.get("remote_files/plugins")
@@ -117,19 +139,3 @@ class PosixFileSourceIntegrationTestCase(integration_util.IntegrationTestCase):
 
     def _assert_access_forbidden_response(self, response):
         api_asserts.assert_status_code_is(response, 403)
-
-    def _write_file_fixtures(self):
-        root = PosixFileSourceIntegrationTestCase.root_dir
-        if os.path.exists(root):
-            shutil.rmtree(root)
-        os.mkdir(root)
-
-        with open(os.path.join(root, "a"), "w") as f:
-            f.write("a\n")
-
-        subdir1 = os.path.join(root, "subdir1")
-        os.mkdir(subdir1)
-        with open(os.path.join(subdir1, "b"), "w") as f:
-            f.write("b\n")
-
-        return root
diff --git a/test/integration_selenium/test_upload_file_sources.py b/test/integration_selenium/test_upload_file_sources.py
new file mode 100644
index 00000000000..2b4f34e2b4f
--- /dev/null
+++ b/test/integration_selenium/test_upload_file_sources.py
@@ -0,0 +1,24 @@
+from .framework import (
+    selenium_test,
+    SeleniumIntegrationTestCase,
+)
+from ..integration.test_remote_files_posix import (
+    PosixFileSourceSetup,
+)
+
+
+class PosixFileSourceSeleniumIntegrationTestCase(PosixFileSourceSetup, SeleniumIntegrationTestCase):
+    # For simplicity, otherwise need to setup a different file_sources_config_file
+    requires_admin = True
+
+    @selenium_test
+    def test_upload_from_posix(self):
+        self.admin_login()
+        self.components.upload.start.wait_for_and_click()
+        self.components.upload.ftp_add.wait_for_and_click()
+        self.components.upload.file_source_selector(path='gxfiles://posix_test').wait_for_and_click()
+        self.components.upload.file_source_selector(path='gxfiles://posix_test/a').wait_for_and_click()
+        self.components.upload.file_dialog_ok.wait_for_and_click()
+        self.upload_start()
+        self.sleep_for(self.wait_types.UX_RENDER)
+        self.wait_for_history()