diff --git a/tools/ncbi_blast_plus/ncbi_blastn_wrapper.xml b/tools/ncbi_blast_plus/ncbi_blastn_wrapper.xml
index c4363881491..c3965ad6288 100644
--- a/tools/ncbi_blast_plus/ncbi_blastn_wrapper.xml
+++ b/tools/ncbi_blast_plus/ncbi_blastn_wrapper.xml
@@ -7,6 +7,7 @@
        -task $blast_type
        -evalue $evalue_cutoff
        $adv_opts.filter_query
+       $adv_opts.strand
        -out $output1
        -outfmt $out_format
        -num_threads 8
@@ -42,10 +43,16 @@
             </param>
             <when value="basic">
                 <param name="filter_query" type="hidden" value="" />
+                <param name="strand" type="hidden" value="" />
             </when>
             <when value="advanced">
                 <!-- Could use a select (yes, no, other) where other allows setting 'level window linker' -->
                 <param name="filter_query" type="boolean" label="Filter out low complexity regions (with DUST)" truevalue="-dust yes" falsevalue="-dust no" checked="true" />
+                <param name="strand" type="select" label="Query strand(s) to search against database/subject">
+                    <option value="-strand both">Both</option>
+                    <option value="-strand plus">Plus (forward)</option>
+                    <option value="-strand minus">Minus (reverse complement)</option>
+                </param>
             </when>
         </conditional>
     </inputs>
diff --git a/tools/ncbi_blast_plus/ncbi_blastx_wrapper.xml b/tools/ncbi_blast_plus/ncbi_blastx_wrapper.xml
index 9183dd779f2..e38c404719c 100644
--- a/tools/ncbi_blast_plus/ncbi_blastx_wrapper.xml
+++ b/tools/ncbi_blast_plus/ncbi_blastx_wrapper.xml
@@ -6,6 +6,7 @@
        -db "$database"
        -evalue $evalue_cutoff
        $adv_opts.filter_query
+       $adv_opts.strand
        -out $output1
        -outfmt $out_format
        -num_threads 8
@@ -34,10 +35,16 @@
             </param>
             <when value="basic">
                 <param name="filter_query" type="hidden" value="" />
+                <param name="strand" type="hidden" value="" />
             </when>
             <when value="advanced">
                 <!-- Could use a select (yes, no, other) where other allows setting 'window locut hicut' -->
                 <param name="filter_query" type="boolean" label="Filter out low complexity regions (with SEG)" truevalue="-seg yes" falsevalue="-seg no" checked="true" />
+                <param name="strand" type="select" label="Query strand(s) to search against database/subject">
+                    <option value="-strand both">Both</option>
+                    <option value="-strand plus">Plus (forward)</option>
+                    <option value="-strand minus">Minus (reverse complement)</option>
+                </param>
             </when>
         </conditional>
     </inputs>
diff --git a/tools/ncbi_blast_plus/ncbi_tblastx_wrapper.xml b/tools/ncbi_blast_plus/ncbi_tblastx_wrapper.xml
index f304a59713e..71e67532a62 100644
--- a/tools/ncbi_blast_plus/ncbi_tblastx_wrapper.xml
+++ b/tools/ncbi_blast_plus/ncbi_tblastx_wrapper.xml
@@ -6,6 +6,7 @@
        -db "$database"
        -evalue $evalue_cutoff
        $adv_opts.filter_query
+       $adv_opts.strand
        -out $output1
        -outfmt $out_format
        -num_threads 8
@@ -34,10 +35,16 @@
             </param>
             <when value="basic">
                 <param name="filter_query" type="hidden" value="" />
+                <param name="strand" type="hidden" value="" />
             </when>
             <when value="advanced">
                 <!-- Could use a select (yes, no, other) where other allows setting 'window locut hicut' -->
                 <param name="filter_query" type="boolean" label="Filter out low complexity regions (with SEG)" truevalue="-seg yes" falsevalue="-seg no" checked="true" />
+                <param name="strand" type="select" label="Query strand(s) to search against database/subject">
+                    <option value="-strand both">Both</option>
+                    <option value="-strand plus">Plus (forward)</option>
+                    <option value="-strand minus">Minus (reverse complement)</option>
+                </param>
             </when>
         </conditional>
     </inputs>