diff --git a/scripts/common_startup.sh b/scripts/common_startup.sh
index 5902644992c..ba91a7226fa 100755
--- a/scripts/common_startup.sh
+++ b/scripts/common_startup.sh
@@ -18,7 +18,6 @@ CREATE_VENV=1
 REPLACE_PIP=$SET_VENV
 COPY_SAMPLE_FILES=1
 SKIP_CLIENT_BUILD=${GALAXY_SKIP_CLIENT_BUILD:-0}
-CLIENT_DEV_SERVER=${GALAXY_CLIENT_DEV_SERVER:-0}
 NODE_VERSION=${GALAXY_NODE_VERSION:-"$(cat client/.node_version)"}
 
 for arg in "$@"; do
@@ -33,11 +32,6 @@ for arg in "$@"; do
     [ "$arg" = "--skip-client-build" ] && SKIP_CLIENT_BUILD=1
 done
 
-# If a client dev server is being configured, skip the client build.
-if [ $CLIENT_DEV_SERVER -ne 0 ]; then
-    SKIP_CLIENT_BUILD=1
-fi
-
 SAMPLES="
     lib/tool_shed/scripts/bootstrap_tool_shed/user_info.xml.sample
     tool-data/shared/ucsc/builds.txt.sample
diff --git a/scripts/get_uwsgi_args.py b/scripts/get_uwsgi_args.py
index 2ca9cf60934..8ab8a552997 100644
--- a/scripts/get_uwsgi_args.py
+++ b/scripts/get_uwsgi_args.py
@@ -107,14 +107,6 @@ def _get_uwsgi_args(cliargs, kwargs):
     if not __arg_set('virtualenv', uwsgi_kwargs) and ('VIRTUAL_ENV' in os.environ or os.path.exists('.venv')):
         __add_arg(args, 'virtualenv', os.environ.get('VIRTUAL_ENV', '.venv'))
 
-    # Client dev server for HMR
-    hmr_server = os.environ.get('GALAXY_CLIENT_DEV_SERVER', None)
-    if hmr_server:
-        # Something like this, which is the default in the package scripts
-        # route: ^/static/scripts/bundled/ http:127.0.0.1:8081
-        if hmr_server.lower() in ['1', 'true', 'default']:
-            hmr_server = "http:127.0.0.1:8081"
-        __add_arg(args, 'route', f'^/static/dist/ {hmr_server}')
     # We always want to append client/src/assets as static-safe.
     __add_arg(args, 'static-safe', f'{os.getcwd()}/client/src/assets')